Nimesulide + Tizanidine Tablet 100mg + 2mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100mg + 2mg

Reference Brands: Various Indian brand

Category: Analgesic

Nimesulide + Tizanidine is a combination of two medicines: Nimesulide and Tizanidine which relieve muscle pain.

Product Description:

This tablet combines nimesulide, a COX-2 preferring NSAID, with tizanidine, a centrally acting alpha-2 adrenergic agonist muscle relaxant. Nimesulide reduces pain and inflammation; tizanidine reduces spasticity and reflex muscle spasm by decreasing excitatory transmission in the spinal cord. The pairing targets musculoskeletal pain accompanied by muscle spasm.

Both components carry constraints that matter here. Nimesulide is restricted in the European Union to second-line short-course use because of hepatotoxicity, was never approved in the US, and has been withdrawn in several countries. Tizanidine causes sedation, dry mouth and hypotension, is metabolised by CYP1A2 so that fluvoxamine and ciprofloxacin raise its levels sharply, and requires liver monitoring itself. Combining two drugs that each carry a liver signal in one tablet concentrates that risk, and it removes the ability to titrate either component independently.

Sourcing notes. An Indian-market fixed-dose combination that is not registrable in most regulated markets, where the components are prescribed separately if at all. Confirm the destination regulator's position on both the combination and on nimesulide itself before quoting, and expect the product to need its own bioequivalence data.