Nimesulide 100 mg/ml Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 100 mg/ml

Reference Brands: -

Category: Veterinary Product

Nimesulide is a COX2-specific NSAID. It is commonly used to reduce the pain and inflammation associated with osteoarthritis in dogs. In addition, nimesulide has a range of other anti-inflammatory effects, including inhibition of the neutrophil oxidative response and inhibition of platelet activating factor.

Product Description:

Nimesulide is a sulphonanilide non-steroidal anti-inflammatory with relative selectivity for COX-2, the enzyme induced at sites of inflammation, over COX-1, which maintains gastric mucosa and platelet function. That selectivity is the rationale for its use: analgesia and anti-inflammatory effect with less of the gastric ulceration that limits older NSAIDs. It also inhibits the neutrophil oxidative burst and platelet activating factor, which are effects the older drugs do not share.

In veterinary practice the injectable form is used for pain and inflammation associated with musculoskeletal conditions, particularly osteoarthritis in dogs, and for inflammatory conditions in larger species. NSAID cautions apply across species: renal injury in dehydrated or hypotensive animals, gastrointestinal ulceration on prolonged use, and no combination with corticosteroids or a second NSAID.

Sourcing notes. One restriction dominates and must be established before any quotation. Nimesulide is toxic to Gyps vultures, which feed on livestock carcasses, and its use in cattle is prohibited or restricted in India and other South Asian markets for that reason — the same conservation measure that removed diclofenac from veterinary use. Confirm the destination market and the intended species. Human nimesulide is also restricted or withdrawn in several countries over hepatotoxicity.