Hydroxyzine Injectable Solution (IM) 25 mg/mL, 50 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injectable solution (IM)

Available Strengths: 25 mg/mL, 50 mg/mL

Reference Brands: US: Vistaril®, Atarax®; EU: Atarax®, Ucerax®

Category: Antipsychotropic Drugs

Hydroxyzine hydrochloride injection 25 mg/mL and 50 mg/mL, for intramuscular use only, used for acute anxiety, agitation and peri-operative sedation. For hospital buyers, tender buyers, importers and distributors.

Product Description:

Hydroxyzine injection is a sterile solution of hydroxyzine hydrochloride at 25 mg/mL or 50 mg/mL, for intramuscular use only. It is the same sedating H1 antihistamine as the oral products, but this form belongs in wards, emergency rooms and theatres, where a patient cannot take tablets or needs faster calming. It goes deep into a large muscle. Intravenous, subcutaneous and intra-arterial routes are contraindicated because they can cause serious tissue damage and thrombosis.

Labelled uses include the acutely agitated or anxious patient, alcohol withdrawal with anxiety, and use before and after surgery or delivery. There it can allow lower opioid doses and helps control nausea and vomiting, though not nausea of pregnancy. In adults, nurses inject into the upper outer buttock or mid-lateral thigh and rotate sites. Sedation adds to that of opioids, barbiturates and alcohol, so doses of other CNS depressants are often reduced. The QT warnings for oral hydroxyzine apply here too.

Sourcing notes. Hydroxyzine injection is prescription-only, and its availability in Europe varies by country. As a sterile product it needs a GMP certificate covering sterile manufacture, and each batch CoA should report sterility, bacterial endotoxins, particulate matter and assay. Vials are typically type I glass. Ask whether multi-dose vials contain benzyl alcohol, which matters for neonatal use. Store at room temperature, protected from light; no cold chain is needed. Request the dossier, stability data for the destination climatic zone and a CoPP. Specify strength, vial type, fill volume and label language.