Fosfomycin IV 2 g, 4g per vial Suppliers & Bulk Manufacturers

Available Forms: Intravenous (IV)

Available Strengths: 2 g, 4g per vial

Reference Brands: Fomicyt (UK), InfectoFos (DE)

Category: Antibiotics

Fosfomycin sodium powder for intravenous infusion in 2 g and 4 g vials, a reserve antibiotic for serious and resistant infections, for hospital pharmacies, importers and antimicrobial tender buyers.

Product Description:

Fosfomycin is a small antibiotic unlike any other class in use. It blocks MurA, the enzyme for the first committed step of bacterial cell wall synthesis, so cross-resistance with other antibiotics is uncommon. The intravenous form is fosfomycin sodium, a sterile powder in 2 g and 4 g vials for reconstitution and infusion. High IV doses reach bone, lung and cerebrospinal fluid.

WHO places IV fosfomycin in the Reserve group of its AWaRe classification. Where registered, uses include complicated urinary tract infection, osteomyelitis, hospital-acquired pneumonia and bacterial meningitis when other antibiotics are unsuitable. It is normally combined with another active drug, because resistance can emerge on monotherapy. Doses are divided through the day and adjusted for kidney function. Each gram carries a large sodium load, which matters in heart failure and oedema, and low potassium is common. IV fosfomycin is not approved in the United States; several European countries authorise it with restricted indications.

Sourcing notes. Because registration of the IV form is patchy, check its status in the destination market first. Ask for a CTD or ACTD dossier covering sterile powder filling, with stability data for your climatic zone, including IVb where relevant. The powder is very hygroscopic, so closure integrity and water content matter. Vials are kept at room temperature, with no cold chain. Request a CoA per batch with assay, water content, pH after reconstitution, sterility and bacterial endotoxins, plus the GMP certificate and a CoPP. Ask for sodium content per vial on the label.