Econazole Nitrate 1% Suppliers & Bulk Manufacturers

Available Forms: Creams / Foam

Available Strengths: 1%

Reference Brands: Ecoza (USA), Pevaryl (EU/UK) , Spectazole (USA)

Category: Anti-fungal

Econazole is a topical antifungal medication that works by inhibiting fungal ergosterol synthesis (via lanosterol 14-alpha-demethylase), thereby treating dermatophyte and yeast skin infections such as tinea pedis (athlete’s foot), tinea cruris, tinea corporis, pityriasis versicolor and cutaneous candidiasis.

Product Description:

Econazole is an imidazole antifungal that inhibits ergosterol synthesis, disrupting the fungal cell membrane. It has a broad spectrum covering dermatophytes, Candida and Malassezia, and it also has useful activity against some Gram-positive bacteria — helpful in skin infections where fungal and bacterial involvement overlap, as they often do in macerated skin folds.

It is used for tinea pedis, cruris and corporis, cutaneous candidiasis and pityriasis versicolor, applied once or twice daily for two to four weeks depending on the site. Treatment should continue for a week or two after the rash clears, because stopping at symptom resolution is the commonest reason infections recur. A foam formulation exists for tinea pedis, designed to spread easily between toes and dry quickly, which addresses the practical problem that greasy creams in that site keep the skin moist. Local burning, stinging and itching are the usual adverse effects.

Sourcing notes. Off patent, with wide generic availability, and over the counter in several markets. Cream, foam, lotion, powder and vaginal presentations are separate registrations. The foam is a pressurised product, which adds propellant compliance and flammability classification to shipping.