Duloxetine 20mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 20mg

Reference Brands: Yentreve (EU/UK),

Category: Antipsychotropic Drugs

Duloxetine is used to treat depression in adults and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer) in adults and children 7 years of age and older.

Product Description:

Duloxetine inhibits reuptake of both serotonin and noradrenaline. The noradrenergic action is what distinguishes it from SSRIs and underlies its two non-psychiatric uses: pain relief, through the descending inhibitory pathways in the spinal cord, and increased urethral sphincter tone, through effects on the pudendal nerve.

The 20 mg capsule is the strength used for stress urinary incontinence in women, where it increases sphincter contraction during bladder filling and reduces leakage episodes; that indication is registered in Europe but not the US. Higher strengths are used for depression, generalised anxiety disorder, diabetic neuropathic pain and fibromyalgia. Nausea is the most common adverse effect and the usual reason for stopping, particularly at the start; it settles for most patients. Discontinuation symptoms are prominent if it is stopped abruptly, so it is tapered. It raises blood pressure modestly, is avoided in uncontrolled hypertension and significant hepatic impairment, and is a CYP2D6 inhibitor.

Sourcing notes. Off patent with wide generic availability. The urinary incontinence indication and brand are separate from the psychiatric ones in several markets, so a quotation should state which indication and strength is intended. Capsules are enteric-coated pellets, since the drug is acid-labile, and coating integrity is the critical quality attribute.