Doxecitine + Doxribtimine Suppliers & Bulk Manufacturers
Available Forms: Oral Solution
Available Strengths: 2g+2g
Reference Brands: Kygevvi (USA)
Category: Orphan Drugs
Doxecitine (2′‑deoxycytidine) and doxribtimine (2′‑deoxythymidine) provide nucleosides to restore mitochondrial DNA synthesis in patients with TK2 deficiency. This helps improve mitochondrial function in muscle cells, reduce muscle weakness, delay disease progression, and improve survival. Doxecitine + Doxribtimine is available in Oral Solution and strengths such as 2g+2g. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Doxecitine + Doxribtimine is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.
| Technical Specifications & Supply Details | |
|---|---|
| Lead Time | 7 to 60 days (depending on batch size & schedule) |
| MOQ | As per manufacturer’s batch size |
| COA | Available with every batch |
| Regulatory Dossier / DMF | Available upon request |
| Export Documentation | FSC, COA, Manufacturing License, Product Permission |
| Standards | IP, BP, USP |
| Certifications | WHO-GMP, EU-GMP, USFDA (as applicable) |
Doxecitine + Doxribtimine can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.
The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
This combination is used to treat Thymidine Kinase 2 Deficiency (TK2d), a rare, inherited mitochondrial disorder that leads to progressive muscle weakness, breathing problems, and mitochondrial DNA depletion. It is the first and currently only approved therapy targeting the underlying cause of TK2d, aiming to restore mitochondrial DNA replication and improve cell energy metabolism.
Doxecitine is a pyrimidine nucleoside — chemically deoxycytidine — and Doxribtimine is deoxythymidine (thymidine nucleoside). Together they supply deoxynucleosides needed for mitochondrial DNA synthesis. The formulation also contains inactive excipients that permit the preparation of an oral solution.
The trade name for this combination is Kygevvi.
Kygevvi is manufactured by UCB, Inc..
The generic names are doxecitine and doxribtimine.
The brand name is Kygevvi.
Kygevvi is produced by UCB, Inc. in regulated pharmaceutical manufacturing facilities and supplied under globally approved Good Manufacturing Practice (GMP) standards.
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