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Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection shortage (US): status and presentations

Shortage United States Β· first listed 20 February 2018 Β· updated 15 October 2026

Dosage formInjection
Therapy areaAnesthesia
Presentations9 unavailable, 0 limited, 11 available
SourceUS FDA Drug Shortage Database (openFDA), checked 19 October 2026

Presentations affected

  • Bupivacaine Hydrochloride And Epinephrine, Injection, 25 mg/10 mL (2.5 mg/mL) β€” Unavailable
  • Bupivacaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (5 mg/mL) β€” Unavailable
  • Bupivacaine Hydrochloride And Epinephrine, Injection, 50 mg/10 mL (5 mg/mL) β€” Unavailable
  • Bupivacaine Hydrochloride And Epinephrine, Injection, 75 mg/30 mL (2.5 mg/mL) β€” Unavailable
  • Bupivacaine Hydrochloride and Epinephrine, Injection, 125 mg/50 mL (2.5 mg/mL) β€” Unavailable
  • Bupivacaine Hydrochloride and Epinephrine, Injection, 150 mg/30 mL (5 mg/mL) β€” Unavailable
  • Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL β€” Unavailable
  • Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL β€” Unavailable
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 125 mg/50 mL (2.5 mg/mL 1:200,000) β€” Available
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 150 mg/30 mL (5 mg/mL 1:200,000) β€” Available
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 25 mg/10 mL (2.5 mg/mL 1:200,000) β€” Available
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 250 mg/50 mL (5 mg/mL 1:200,000) β€” Available
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 50 mg/10 mL (5 mg/mL 1:200,000) β€” Available
  • Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 75 mg/30 mL (2.5 mg/mL 1:200,000) β€” Available
  • Sensorcaine, Injection, 7.5 mg/1 mL; .005 mg/1 mL β€” Available

Strengths and packs as listed by the regulator. Manufacturer names and product codes are not shown.

What buyers can do

  • Check whether other registered presentations or strengths can be used, and ask your wholesaler about allocation.
  • For hospital and tender supply, look for manufacturers that already hold an approval in your market and can increase output.
  • In a critical shortage, the FDA can allow temporary importation of a version approved in a well-regulated market. That decision is made by the FDA, case by case.
  • Qualify any new source as carefully as at any other time: GMP certificate, registration status and a certificate of analysis for each batch.

More: where licensed suppliers can step in during US shortages.

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For information only. Shortage status changes often; confirm with the regulator before making decisions. Brand names, where shown, are trademarks of their owners.

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