Ziprasidone Intramuscular Injection 20 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Intramuscular Injection (IM)

Available Strengths: 20 mg/mL

Reference Brands: Zeldox®(EU); Geodon®(US)

Category: Antipsychotropic Drugs

Ziprasidone mesylate for intramuscular injection, 20 mg/mL after reconstitution, a hospital antipsychotic for acute agitation in schizophrenia, for importers, hospital pharmacies and tender buyers.

Product Description:

Ziprasidone is a second-generation antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors. The intramuscular form is ziprasidone mesylate, a freeze-dried powder in a single-dose vial that gives 20 mg/mL once reconstituted with water for injection. A cyclodextrin carrier lets the poorly soluble drug dissolve. This injection exists for one job: settling acute agitation in a patient who cannot or will not take tablets.

It is approved for short-term control of acute agitation in adults with schizophrenia. Doses are 10 mg up to every 2 hours or 20 mg up to every 4 hours, to a maximum of 40 mg a day; use beyond three consecutive days has not been studied. It is given intramuscularly only, never intravenously. Ziprasidone prolongs the QT interval, so it is avoided with other QT-prolonging drugs, after a recent heart attack and in uncompensated heart failure. The cyclodextrin is cleared by the kidneys, so renal impairment needs care. Older people with dementia-related psychosis face a higher risk of death on antipsychotics.

Sourcing notes. This is a prescription-only hospital injectable. Ask for a CTD or ACTD dossier covering sterile manufacture with a validated lyophilisation process. Confirm whether water for injection is packed with the vial or ordered separately. The dry vial is kept at room temperature, protected from light. Request a CoA per batch covering assay, related substances, water content, sterility and bacterial endotoxins, plus the GMP certificate, a CoPP and zone IVb stability data for hot humid markets.