Tramadol Hydrochloride Tablets Suppliers & Bulk Manufacturers

Available Forms: Tablets(IR/ER)/ Capsules

Available Strengths: Capsules, Tablet(IR: 50 mg; ER:00 mg, 200 mg, and 300 mg)

Reference Brands: Ultram(US)

Category: Active Pharmaceutical Ingredient

Tramadol hydrochloride 50 mg immediate-release tablets and capsules and 100-300 mg extended-release tablets, an opioid analgesic. For licensed importers, hospitals and distributors holding the required permits.

Product Description:

Tramadol hydrochloride is a centrally acting opioid analgesic with a dual action. It is a weak mu-opioid agonist, mostly through its metabolite O-desmethyltramadol, formed in the liver by CYP2D6, and it also blocks serotonin and noradrenaline reuptake. This page covers immediate-release 50 mg tablets and capsules for acute pain, and extended-release tablets at 100 mg, 200 mg and 300 mg for once-daily use in chronic pain. Extended-release tablets are swallowed whole, because crushing can release the full dose at once.

Tramadol is used for moderate to moderately severe pain when non-opioid analgesics are not enough. Pharmacists check the opioid risks: dependence and misuse, respiratory depression, and heavy sedation with benzodiazepines, alcohol or other CNS depressants. It lowers the seizure threshold and can cause serotonin syndrome with SSRIs, SNRIs, tricyclics and MAO inhibitors. Ultra-rapid CYP2D6 metabolisers can reach high levels of the active metabolite, which is why several regulators restrict use in children.

Sourcing notes. Tramadol is a controlled medicine in many countries; it is Schedule IV in the United States and a Schedule 3 controlled drug in the UK. Supply moves only when the importer holds the required import permit and the exporter the matching export authorisation, both in place before an order is confirmed. Ask for a CTD or ACTD dossier with bioequivalence data, including fed and fasted studies and multi-point dissolution for extended-release tablets. Request Zone IVb stability where relevant, a CoA per batch, the GMP certificate and a CoPP. Quote the release type and permit details when you enquire.