Protionamide

Form: Tablet

Strength: 250 mg

Reference Brands: Prothion,Prothionamide(India)

Category: Respiratory Disorder

Protionamide is an oral thioamide antibiotic used in the treatment of multidrug-resistant tuberculosis (MDR-TB) and leprosy. It works by inhibiting mycolic acid synthesis, essential for the bacterial cell wall. Protionamide is structurally and functionally similar to ethionamide and is often used in combination with other second-line anti-TB drugs. Available as a 250 mg tablet, it is commonly used in India and select EU countries, but not approved in the United States. Side effects include gastrointestinal discomfort, hepatotoxicity, and peripheral neuropathy, which can be mitigated with vitamin B6 supplementation. It plays a vital role in MDR-TB management.