Ethionamide Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 250 mg

Reference Brands: Generic formulations marketed under different names

Category: Respiratory Disorder

Product Description:

Ethionamide, also known as ETA or ETH, is an oral antibiotic used primarily in the treatment of tuberculosis, particularly multidrug-resistant tuberculosis (MDR-TB). It is used in combination with other antituberculosis medications as part of a second-line regimen to ensure effective bacterial eradication and prevent the development of further drug resistance.

Ethionamide exhibits antimicrobial activity against Mycobacterium tuberculosis, M. bovis, and M. smegmatis, and is occasionally used against M. leprae and other nontuberculous mycobacteria, including M. avium and M. kansasii. It works by inhibiting mycolic acid synthesis in the bacterial cell wall, preventing bacterial growth and replication. While its mechanism is similar to isoniazid, cross-resistance occurs in only a small percentage of strains because both drugs are prodrugs activated by different pathways.

Ethionamide is administered orally under medical supervision, usually as part of a combination therapy. Regular monitoring is recommended to assess treatment efficacy and detect potential side effects, including gastrointestinal disturbances and hepatotoxicity. Its targeted activity against resistant mycobacterial strains makes ethionamide a valuable option in the management of complex tuberculosis infections.