Methacholine Chloride Suppliers & Bulk Manufacturers
Available Forms: Inhalation solution
Available Strengths: 0.25 mg/mL, 0.5 mg/mL, 1 mg/mL, 2 mg/mL
Reference Brands: Provocholine (USA)
Category: Respiratory Disorder
Methacholine chloride is inhaled in increasing doses during a bronchial challenge test to help diagnose asthma when standard breathing tests are normal. It is supplied as powder for preparing solutions (for example 0.25 to 16 mg/ml). The reference product is Provocholine, and few manufacturers make it. Ask PharmaTradz for a quote; we confirm the manufacturer, registration documents and lead time for your country.
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Product Description:
Methacholine chloride is a diagnostic agent primarily used to assess bronchial hyperreactivity, a defining feature of asthma and a condition that may also be present in chronic obstructive pulmonary disease (COPD). Its main clinical application is in the methacholine challenge test, a controlled pulmonary function test designed to evaluate airway responsiveness. During this procedure, the patient inhales increasing concentrations of aerosolized methacholine, which induces temporary bronchoconstriction in susceptible individuals. The degree of airway narrowing is then measured to help confirm or rule out asthma.
Methacholine acts as a direct cholinergic agonist, stimulating muscarinic receptors in the airways and causing smooth muscle contraction. Due to this mechanism, its use is strictly limited to diagnostic settings and is performed under close medical supervision with appropriate resuscitation measures readily available.
Therapeutic use of methacholine is minimal and uncommon because of its potential systemic effects. As a cholinomimetic agent, it can produce adverse cardiovascular reactions such as bradycardia and hypotension, particularly if absorbed systemically. For this reason, methacholine chloride is reserved exclusively for diagnostic purposes in specialized respiratory laboratories and hospitals, where it serves as a reliable and well-established tool for evaluating airway hyperresponsiveness and supporting accurate respiratory diagnosis.
Also known as: metacolina (Spanish, Italian), méthacholine (French), Methacholin (German), metakolin (Turkish), 醋甲胆碱 (Chinese).
Methacholine Chloride — third party manufacturing & bulk supply
Methacholine Chloride is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
Indicative minimum order quantity
Methacholine Chloride is supplied as Inhalation solution — a dosage form priced by order value, so the indicative MOQ is a minimum order value of USD 5,000 per product. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.
Manufacturers of Methacholine Chloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.
Request a quote for Methacholine Chloride →Usually answered within 48 hours, with matched manufacturers, indicative prices and document status.
Frequently Asked Questions
Methacholine chloride is used in bronchial challenge testing to diagnose airway hyperreactivity, which is commonly associated with asthma.
Methacholine chloride is a synthetic choline ester formulated as a sterile solution for inhalation during diagnostic testing.
Methacholine chloride is marketed under the trade name Provocholine in the USA and as generic inhalation solutions in the UK and EU.
Several companies make it, in India and elsewhere. Tell us your market and we will match you with licensed makers whose documents fit.
The generic name is methacholine chloride.
Provocholine (USA), generic versions in UK/EU.
Methacholine chloride is manufactured in the USA, EU, and other countries by licensed pharmaceutical companies producing diagnostic inhalation solutions.
The patient inhales increasing concentrations while lung function (FEV1) is measured; a 20% fall at a low dose suggests asthma.
A doctor and rescue bronchodilator must be available, and the test is not done if baseline lung function is poor.
As powder (for example 100 mg vials) reconstituted and diluted by the pharmacy into the required concentrations.
El cloruro de metacolina es un agente diagnóstico que se inhala durante la prueba de provocación bronquial para medir la hiperreactividad de las vías respiratorias y ayudar en el diagnóstico del asma; no es un tratamiento. La prueba se realiza en un laboratorio de función pulmonar bajo la supervisión de un especialista. PharmaTradz pone en contacto a importadores con licencia, distribuidores y hospitales con fabricantes de metacolina que cuentan con certificación GMP.
O cloreto de metacolina é um agente diagnóstico inalado no teste de broncoprovocação para avaliar a hiper-responsividade das vias aéreas e auxiliar no diagnóstico da asma; não é um tratamento. O teste é realizado em laboratório de função pulmonar, sob supervisão de um especialista. A PharmaTradz conecta importadores autorizados, distribuidores e hospitais a fabricantes de metacolina com certificação GMP.
Le chlorure de méthacholine est un agent de diagnostic inhalé lors du test de provocation bronchique, qui permet d'évaluer l'hyperréactivité des voies aériennes et d'aider au diagnostic de l'asthme ; ce n'est pas un traitement. Le test est réalisé dans un laboratoire d'explorations fonctionnelles respiratoires, sous la surveillance d'un spécialiste. PharmaTradz met en relation les importateurs agréés, les distributeurs et les hôpitaux avec des fabricants de méthacholine certifiés GMP.
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