Propafenone Tablet 150 mg, 300 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 150 mg, 300 mg

Reference Brands: Rhythmol(US & EU)

Category: Heart Disorder

Propafenone 150 mg and 300 mg tablets, a class IC antiarrhythmic used under specialist care to keep normal heart rhythm. Suited to importers, distributors, hospital pharmacies and cardiology tender buyers.

Product Description:

Propafenone is a class IC antiarrhythmic. It blocks fast sodium channels in heart muscle, slowing conduction and suppressing abnormal impulses, and it has a mild beta-blocking effect too. This page covers film-coated tablets of 150 mg and 300 mg. These immediate-release tablets are taken in divided doses through the day, and the two strengths let the cardiologist adjust the total to body weight, response and the ECG. Patients swallow the tablet whole because the drug tastes bitter and numbs the mouth.

Propafenone keeps sinus rhythm in patients with paroxysmal atrial fibrillation or supraventricular tachycardia who have no structural heart disease. It is also used for serious ventricular arrhythmias. Like other class IC drugs, it is avoided after myocardial infarction and in heart failure, where trials showed excess deaths. Treatment starts under specialist care with ECG checks for QRS widening and block. CYP2D6, CYP3A4 and CYP1A2 inhibitors raise its levels, and it raises digoxin and warfarin levels.

Sourcing notes. Propafenone is a prescription-only cardiac medicine, normally supplied to hospitals and specialist pharmacies. Ask for a CTD or ACTD dossier with bioequivalence data and zone IVb stability results if the destination is hot and humid. Tablets usually come in blister packs, stored at room temperature and protected from light; no cold chain is needed. Each batch should arrive with a CoA, backed by the site GMP certificate and a CoPP. When you enquire, give strength, pack size, quantity, label language and any tender specification.