Nimesulide + Serratiopeptidase Tablet 100mg +10mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100mg +10mg

Reference Brands: -

Category: Analgesic

Nimesulide 100 mg and serratiopeptidase 10 mg tablets, an NSAID and enzyme combination prescribed for short-term pain and swelling in some markets. For licensed importers and distributors where registered.

Product Description:

This tablet pairs nimesulide 100 mg, a sulfonanilide NSAID with preferential COX-2 inhibition, and serratiopeptidase 10 mg, a protein-digesting enzyme first isolated from a Serratia bacterium. Nimesulide gives the analgesic and anti-inflammatory effect. Serratiopeptidase is promoted to reduce swelling, but good clinical evidence for this is limited. Because stomach acid would destroy the enzyme, it sits in an enteric-coated layer or bilayer tablet, so coating quality is central. Enzyme strength is often stated in units as well as milligrams.

It is prescribed in some markets for short-term pain and swelling after dental or minor surgery and injury. Nimesulide's main hazard is liver injury, which led several countries to withdraw it and others never to approve it; the United States has never authorised it. In the EU it is limited to second-line use for acute pain and primary dysmenorrhoea, for no more than 15 days, and not in children under 12. Other NSAID warnings apply. Serratiopeptidase may add to bleeding risk with anticoagulants.

Sourcing notes. Check registration first, because nimesulide is unavailable in many markets and its fixed pairing with an enzyme is accepted by fewer still. This is a medicine, so any CE mark offered with it is a red flag about the supplier's paperwork. Ask for a CoA per batch showing nimesulide assay and dissolution, enzyme activity in units, and acid-resistance testing of the enteric coat. Enzyme activity falls with heat and moisture, so alu-alu blisters and zone IVb stability data matter. Request the GMP certificate, a CoPP and the registration dossier.