What is Midodrine made from?

Midodrine is the active ingredient midodrine hydrochloride, a synthetic alphaâ1 adrenergic agonist that constricts blood vessels.

Midodrine hydrochloride bulk supplier for pharma manufacturers

Midodrine Hydrochloride 2.5 mg, 5 mg, 10 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 2.5 mg, 5 mg, 10 mg

Reference Brands: ProAmatine (USA/EU)

Category: Heart Disorder

Midodrine is a selective alpha‑1 adrenergic agonist that works by constricting blood vessels to increase blood pressure. It is primarily used to treat symptomatic orthostatic hypotension — a condition where blood pressure falls when a person stands up, causing dizziness and fainting. It is typically prescribed when other measures (like increased fluid/salt intake) are insufficient. Common side effects may include piloerection (“goosebumps”), scalp tingling, urinary retention, and supine hypertension.

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Product Description:

Midodrine is a prodrug converted to desglymidodrine, a selective alpha-1 adrenergic agonist. It constricts both arteries and veins, raising blood pressure by increasing peripheral resistance and venous return. It does not cross into the brain and has no direct cardiac effect, so it raises blood pressure without stimulating the heart.

It is used for symptomatic orthostatic hypotension, and it is also used off label to support blood pressure in dialysis and in cirrhosis with refractory ascites, and to help wean patients off intravenous vasopressors. Its central drawback mirrors the disease: it raises blood pressure lying down as well as standing, so supine hypertension carries a boxed warning in the US, the last dose is taken at least three or four hours before lying down, and patients sleep with the head raised. Scalp tingling, goosebumps and urinary retention follow from alpha stimulation. It was approved on surrogate evidence, and its effect on long-term outcomes has been debated.

Sourcing notes. Off patent with generics available in the US and Europe. Demand is steady from autonomic, nephrology and hepatology clinics. Tablets are simple immediate-release products, and the three strengths support titration.

Midodrine Hydrochloride — third party manufacturing & bulk supply

Midodrine Hydrochloride 2.5 mg, 5 mg, 10 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Midodrine Hydrochloride is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Midodrine Hydrochloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Midodrine is used to treat low blood pressure that occurs upon standing (orthostatic hypotension) by increasing vascular tone and blood pressure.

Midodrine is the active ingredient midodrine hydrochloride, a synthetic alpha‑1 adrenergic agonist that constricts blood vessels.

The main trade name is ProAmatine.

Midodrine and its branded form ProAmatine are manufactured by various pharmaceutical companies depending on the region; the brand ProAmatine is marketed by specific licensed manufacturers in the USA.

The generic name is midodrine hydrochloride.

The primary brand name is ProAmatine.

Midodrine products are manufactured by licensed pharmaceutical producers in different countries; specific manufacturing sites vary by company and regional approvals.