Lercanidipine 10mg, 20mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10mg, 20mg

Reference Brands: Zanidip (EU/UK), Lercadip (EU/UK)

Category: Heart Disorder

Lercanidipine is a calcium channel blocker (dihydropyridine class) used primarily for the treatment of hypertension (high blood pressure). It works by relaxing and widening blood vessels, allowing blood to flow more easily and reducing the workload on the heart. Lercanidipine helps prevent complications associated with high blood pressure such as heart attacks, strokes, and kidney damage. It has a long duration of action and is typically administered once daily.

Product Description:

Lercanidipine is a third-generation dihydropyridine calcium channel blocker. It is highly lipophilic, so it partitions into cell membranes and leaves slowly, giving a long duration of action even though plasma levels fall quickly. The gradual onset avoids reflex tachycardia, and its high vascular selectivity means little effect on cardiac contractility. It also dilates efferent as well as afferent renal arterioles, which may help protect the kidney.

It is used once daily for hypertension, including isolated systolic hypertension in older patients. Its practical advantage over amlodipine is a lower rate of ankle oedema in comparative trials, which is the most common reason patients stop a dihydropyridine. Headache, flushing and palpitations can occur. It is taken before food, since a high-fat meal greatly increases absorption. It is a CYP3A4 substrate, so grapefruit juice and strong inhibitors raise levels; it is contraindicated with strong inhibitors and in severe hepatic or renal impairment.

Sourcing notes. Off patent, with generics across Europe, Asia and Latin America, but it is not registered in the US. Film-coated tablets are standard; the active is light-sensitive, so packaging and stability data matter.