Lamivudine Stavudine & Nevirapine Tablets 150mg + 40mg + 200mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 150mg + 40mg + 200mg

Reference Brands: -

Category: Anti Viral

Lamivudine, stavudine and nevirapine 150/40/200 mg tablets, an older fixed-dose HIV regimen now rarely used. For HIV programmes and licensed importers in markets where it is still registered.

Product Description:

This fixed-dose tablet once formed a complete antiretroviral regimen in one: lamivudine 150 mg and stavudine 40 mg, both nucleoside reverse transcriptase inhibitors, with nevirapine 200 mg, a non-nucleoside inhibitor that binds directly to HIV reverse transcriptase. Taken twice daily, it replaced three tablets with one. It is an HIV medicine, not a hepatitis product. The 40 mg stavudine strength is outdated: WHO first cut the adult stavudine dose to 30 mg to reduce toxicity, then advised phasing stavudine out.

WHO guidelines and major regulators have moved to safer regimens, mainly dolutegravir-based, so this combination is now rarely used and supplied only where it remains registered. Stavudine causes peripheral neuropathy, lipoatrophy, lactic acidosis and pancreatitis. Nevirapine can cause severe rash, including Stevens-Johnson syndrome, and serious liver toxicity, especially early in treatment. It also needs a two-week once-daily lead-in, which this fixed tablet cannot provide, and it interacts with rifampicin and hormonal contraceptives. Patients still taking it should be reviewed for a switch.

Sourcing notes. Before ordering, confirm the product still holds a valid registration in the destination country and that the 40 mg stavudine strength is acceptable to the prescriber, since current national guidelines may no longer list it. Tender rules often require WHO prequalification or stringent-authority approval; ask for documentary evidence and its current status. Request a CoA per batch for all three actives, the GMP certificate, a CoPP and zone IVb stability data. Bottles with desiccant are the usual pack, with no cold chain. State quantity and the remaining shelf life you require.