Indinavir Sulphate 200 mg, 400 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 200 mg, 400 mg

Reference Brands: Crixivan®(EU & US)

Category: Anti Viral

Indinavir sulphate 200 mg and 400 mg capsules, an older HIV protease inhibitor now used rarely, for importers, distributors and hospital pharmacies supplying patients in markets where it remains registered.

Product Description:

Indinavir is an HIV protease inhibitor, supplied here as the sulphate salt in 200 mg and 400 mg hard capsules. It binds the viral protease so new virus particles cannot cut their precursor proteins into working parts, and they remain immature and non-infectious. It was one of the first protease inhibitors. WHO guidelines and major regulators have since moved to safer and simpler regimens, and indinavir is now used rarely, mainly where it remains registered.

Unboosted, the adult dose is 800 mg every eight hours on an empty stomach or with a light low-fat meal; with low-dose ritonavir it becomes twice daily. It is always combined with other antiretrovirals. Kidney stones are a known problem, so patients drink at least 1.5 litres of fluid a day. Indinavir is metabolised by CYP3A4: rifampicin and St John's wort lower its levels, and simvastatin, oral midazolam and ergot derivatives are contraindicated with it. Every co-prescription needs pharmacist review.

Sourcing notes. Supply is possible only where a registration is still current, so check the status in your market first. The capsules are sensitive to moisture: they stay in the original bottle with its desiccant, tightly closed, and patients are told not to decant them. Expect a CTD or ACTD dossier with stability for your climatic zone, zone IVb in hot humid regions, and no cold chain. Request batch CoAs showing assay, dissolution and related substances, together with the GMP certificate and a CoPP. It is prescription-only. State strength, bottle count and remaining shelf life required.