Gepirone Hydrochloride Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 54.5 mg, 18.2 mg , 36.3 mg,

Reference Brands: Exxua (USA)

Category: Neurology

Gepirone Hydrochloride is available in Tablets and strengths such as 54.5 mg, 18.2 mg , 36.3 mg,. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Gepirone Hydrochloride is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Gepirone Hydrochloride can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

Product Description:

Gepirone hydrochloride, sold under the brand name Exxua, is an oral medication approved for the treatment of major depressive disorder (MDD) in adults. It belongs to the class of selective serotonin receptor partial agonists and works by modulating serotonergic neurotransmission in the brain, helping to alleviate depressive symptoms and improve mood. Gepirone’s mechanism of action involves partial stimulation of postsynaptic 5-HT1A receptors while modulating presynaptic autoreceptors, which enhances serotonin activity in key brain regions associated with mood regulation.

Clinical studies submitted to the U.S. Food and Drug Administration (FDA) included 15 trials evaluating gepirone for depression. Of these, two pivotal trials demonstrated significant effectiveness, showing that gepirone reduced depressive symptoms by approximately 2.5 points more than placebo on the 17-item Hamilton Depression Rating Scale (HAMD-17). These results were comparable to the effect sizes observed with other approved antidepressants, supporting its efficacy in adults with major depressive disorder. Exxua provides an additional treatment option for patients seeking effective management of depressive symptoms, particularly those who may benefit from its selective serotonergic activity.