Didanosine Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 125 mg, 200 mg, 250 mg, 400 mg

Reference Brands: Videx EC®

Category: Anti Viral

Didanosine delayed-release capsules, 125 mg to 400 mg, an older NRTI antiretroviral for HIV-1. For importers, HIV programmes and tender buyers who still need registered supply for patients on legacy regimens.

Product Description:

Didanosine, also called ddI, is a nucleoside reverse transcriptase inhibitor (NRTI) active against HIV-1. Inside cells it becomes dideoxyadenosine triphosphate, which blocks viral reverse transcriptase and ends the growing chain of viral DNA. Stomach acid destroys the molecule, so early products were buffered chewable tablets. These delayed-release capsules instead hold enteric-coated beadlets that pass the stomach intact and release the drug in the intestine. Strengths here run from 125 mg to 400 mg.

Didanosine was once a standard part of combination therapy, but WHO and major treatment guidelines have moved away from it because of toxicity, and it is not among the regimens they now recommend. Where still prescribed, the capsule is swallowed whole once daily on an empty stomach. Dose is set by body weight and cut in kidney impairment. Serious risks include pancreatitis, peripheral neuropathy, lactic acidosis with fatty liver and non-cirrhotic portal hypertension. Allopurinol and ribavirin are contraindicated, and guidelines advise against pairing it with stavudine or tenofovir disoproxil.

Sourcing notes. Confirm first that didanosine is still listed and registered in the destination market. Ask for the dossier in CTD or ACTD format, with zone IVb stability data for hot humid markets. The enteric coat must be kept dry, so check the bottle closure and storage at controlled room temperature. Ask for a CoA per batch, GMP certificate and CoPP. It is prescription-only. In your enquiry, list strengths, quantities and count per bottle, and say whether WHO prequalification is a tender condition.