Dichlorphenamide 50 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 50 mg

Reference Brands: Keveyis (USA/EU)

Category: Neurology

Dichlorphenamide is a Neurology product available as Tablets in strengths 50 mg. It corresponds to the reference brand Keveyis (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Dichlorphenamide, also known as diclofenamide, is a sulfonamide-based carbonic anhydrase inhibitor belonging to the meta-disulfamoylbenzene class. It is classified as a first-generation carbonic anhydrase inhibitor and has a long history of clinical use across multiple therapeutic areas. The drug works by inhibiting carbonic anhydrase enzymes, leading to alterations in electrolyte balance and cellular excitability.

Historically, dichlorphenamide was approved in the United States in 1958 under the brand name Daranide for the treatment of glaucoma, including acute angle-closure glaucoma. Over time, it was also found to be effective in certain cases of therapy-resistant epilepsy. Further clinical research later established its role in neuromuscular disorders.

In 2015, dichlorphenamide received approval in the United States as an orphan drug under the brand name Keveyis for the treatment of primary periodic paralysis, including both hypokalemic and hyperkalemic forms. By stabilizing muscle membrane excitability, it helps reduce the frequency and severity of paralytic attacks. Due to its pharmacological activity, dichlorphenamide is prescribed under specialist supervision with appropriate clinical monitoring.