Defibrotide Sodium 200 mg Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 200 mg

Reference Brands: Defitelio (USA/EU)

Category: Critical Care

Defibrotide Sodium is a Critical Care product available as Injection in strengths 200 mg. It corresponds to the reference brand Defitelio (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Defibrotide sodium is a polydeoxyribonucleotide-based therapeutic agent with antithrombotic, thrombolytic, and fibrinolytic properties. It is composed of a mixture of single-stranded oligonucleotides purified from porcine intestinal mucosa and formulated as a sodium salt for intravenous administration. Defibrotide sodium is marketed under the brand name Defitelio and is primarily used in the management of hepatic veno-occlusive disease, also known as sinusoidal obstruction syndrome, in patients who have undergone hematopoietic stem cell or bone marrow transplantation.

Defibrotide sodium exerts its activity by protecting the endothelial cells that line blood vessels, particularly within the liver. It promotes the release of prostacyclin (prostaglandin I₂) and reduces the expression of adhesion molecules on endothelial cells. These actions interfere with platelet and leukocyte adhesion to the vascular endothelium, helping to restore endothelial function and maintain microvascular blood flow. Unlike conventional anticoagulants, defibrotide sodium supports fibrinolysis and endothelial stability without causing significant systemic anticoagulation.

Although the precise mechanism of action is not fully understood, defibrotide sodium plays a supportive role in reducing vascular injury and thrombotic complications associated with veno-occlusive disease following transplantation.