Chlorpheniramine Maleate + Codeine

Form: Extended-Release Tablets

Strength: 54.3 mg of codeine; 8 mg of chlorpheniramine maleate

Reference Brands: Tuzistra XR®, Tuxarin ER®(US); Corex®(India)

Category: Respiratory Disorder

Chlorpheniramine Maleate + Codeine is a prescription combination medication used to treat cough, cold, and allergy symptoms. Chlorpheniramine acts as an antihistamine to reduce sneezing and runny nose, while codeine suppresses persistent cough. Available in the US under brands like Tuzistra XR® and Tuxarin ER®, it comes in extended-release tablets and oral solutions. Due to codeine’s opioid nature, it's classified as a Schedule III controlled substance, requiring careful prescribing. Although not widely available in the EU due to stricter opioid regulations, this combo remains in demand for B2B, PCD pharma, and regulated pharmaceutical export markets targeting respiratory relief.