Apraclonidine Hydrochloride Suppliers & Bulk Manufacturers

Available Forms: Eye Drops

Available Strengths: 0.5 %, 1%

Reference Brands: Iopidine (USA)

Category: Opthalmology

Apraclonidine Hydrochloride is available in Eye Drops and strengths such as 0.5 %, 1%. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Apraclonidine Hydrochloride is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Apraclonidine Hydrochloride can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

Product Description:

Apraclonidine Hydrochloride, marketed under the brand name Iopidine, is a sympathomimetic agent used in the management of glaucoma and ocular hypertension. It functions primarily as an α2-adrenergic receptor agonist with weak α1-adrenergic receptor activity, allowing it to reduce intraocular pressure (IOP) by decreasing aqueous humor production and enhancing uveoscleral outflow. Topically applied as an ophthalmic solution, apraclonidine is available in 1% concentration for the prevention and treatment of post-surgical IOP spikes and 0.5% concentration for short-term adjunctive therapy in patients on maximally tolerated medical therapy requiring additional IOP reduction.

Apraclonidine is often administered as one drop one hour prior to laser eye procedures and another immediately after the procedure to prevent acute IOP elevation. In addition to its role in glaucoma management, apraclonidine can aid in the diagnosis of Horner’s syndrome. In this condition, sympathetic innervation to the pupillary dilator is lost, resulting in pupil constriction (miosis). Due to its weak α1 activity, apraclonidine induces a super-normal dilation response in the denervated pupil, helping to reverse anisocoria and confirm the diagnosis. Frequent follow-up is recommended for patients using apraclonidine to ensure efficacy and safety.