Acoltremon 0.003% Suppliers & Bulk Manufacturers

Available Forms: Eye Drops

Available Strengths: 0.003%

Reference Brands: Tryptyr (USA)

Category: Opthalmology

Acoltremon is a Opthalmology product available as Eye Drops in strengths 0.003%. It corresponds to the reference brand Tryptyr (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Acoltremon, marketed in the United States under the brand name TRYPTYR®, is a novel ophthalmic therapy developed for the treatment of the signs and symptoms of dry eye disease. It is formulated as eye drops and acts as a selective agonist of the TRPM8 thermoreceptor, a sensory receptor involved in ocular surface cooling and tear secretion. By activating TRPM8 receptors, acoltremon stimulates natural tear production, helping to restore the aqueous layer of the tear film that is often deficient in patients with dry eye disease.

Insufficient tear production is a key contributor to dry eye symptoms such as irritation, burning, and visual discomfort. Acoltremon addresses this underlying mechanism by promoting physiologic tear secretion rather than suppressing inflammation. During phase III clinical trials, acoltremon demonstrated a significant increase in tear production and showed a favorable safety profile, with a low rate of treatment discontinuation.

The successful clinical development of acoltremon represents an important milestone in dry eye management, introducing a first-in-class mechanism of action. Its approval provides a new therapeutic option for patients seeking effective and well-tolerated treatment for dry eye disease.