Amantadine Hydrochloride Suppliers & Bulk Manufacturers

Available Forms: Tablets, Capsules

Available Strengths: 100 mg, 200 mg, 129 mg, 137 mg

Reference Brands: Symmetrel (USA), Gocovri (USA)

Category: Neurology

Amantadine hydrochloride in immediate-release 100 mg capsules and tablets plus extended-release 129 mg and 137 mg forms, for Parkinson's disease. For importers, distributors and hospital neurology buyers.

Product Description:

Amantadine hydrochloride is an older drug with two quite different actions. It blocks the M2 ion channel of influenza A virus, and in the brain it increases dopamine release and weakly blocks NMDA glutamate receptors. This page lists immediate-release 100 mg capsules and tablets, a 200 mg strength, and extended-release products of 129 mg as tablets and 137 mg as capsules. The extended-release forms give steadier blood levels through the day, and the capsule version is taken at bedtime.

Its main use today is Parkinson's disease, alone early on or with levodopa, and the bedtime extended-release capsule is approved for levodopa-induced dyskinesia. Some labels include drug-induced extrapyramidal reactions. Influenza A use has largely stopped because circulating strains are widely resistant. Amantadine is cleared by the kidneys, so doses are reduced in renal impairment and in older people. Confusion, hallucinations, ankle swelling and a mottled skin pattern called livedo reticularis are recognised effects. Sudden withdrawal can trigger a reaction resembling neuroleptic malignant syndrome, so it is tapered.

Sourcing notes. Amantadine is prescription-only. Immediate-release forms are widely registered, while extended-release products exist in fewer markets, so confirm local registration before quoting. Ask for a CTD or ACTD dossier with bioequivalence data, and dissolution profiles for any extended-release product. Capsules and tablets are stored at room temperature in moisture-protective blisters or bottles, with zone IVb stability for hot, humid regions. Paperwork should include a CoA for each batch, the GMP certificate and a CoPP. State release type, strength, capsule or tablet, pack size, label language and shelf life on arrival.