Alprazolam / Sertraline Tablet 0.25mg + 25mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 0.25mg + 25mg

Reference Brands: Various Indian Brand Available

Category: Antipsychotropic Drugs

Alprazolam + Sertraline is a combination of two medicines: Alprazolam and Sertraline, which has anxiety-lowering and mood-enhancing effects. Alprazolam is a benzodiazepine (BZD) which increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Sertraline is selective serotonin reuptake inhibitor (SSRI) which increases the levels of serotonin, a chemical messenger that improves mood.

Product Description:

A 12-week, placebo-controlled outpatient study was conducted to evaluate the efficacy and safety of sertraline hydrochloride and alprazolam in patients diagnosed with panic disorder, with and without agoraphobia, according to ICD-10 criteria. The study included 40 adult patients aged 18 years and above, who were randomly assigned to receive either sertraline or alprazolam in fixed doses.

Sertraline was administered at a dose of 20 mg per day, while alprazolam was given in doses ranging from 1 to 1.5 mg per day. The evaluation focused on key clinical parameters, including the frequency of panic attacks, severity of agoraphobia, and levels of anticipatory anxiety.

The results demonstrated that both sertraline and alprazolam significantly reduced the frequency of panic attacks in patients with panic disorder. In addition, notable improvements were observed in symptoms of agoraphobia and anticipatory anxiety. These findings highlight the effectiveness of both medications in managing panic disorder, with each offering therapeutic benefits in reducing acute anxiety symptoms and improving overall patient outcomes when used under appropriate medical supervision.