Viral Vector Vaccines 0.5 mL Suppliers & Bulk Manufacturers

Available Forms: Intramuscular injectable suspension (IM)

Available Strengths: 0.5 mL

Reference Brands: Jcovden (US)

Category: Vaccines

Viral vector vaccines, a platform using adenovirus and other modified viruses to deliver antigen genes, given as 0.5 mL intramuscular doses. For ministries of health, UN-agency buyers, licensed importers and hospitals.

Product Description:

Viral vector vaccines use a modified virus to carry a gene for a target antigen into the body's cells, which then make the antigen and present it to the immune system, producing both antibody and T-cell responses. Most vectors in use are replication-deficient adenoviruses of human or chimpanzee origin; others include modified vaccinia Ankara and a replication-competent vesicular stomatitis virus carrying a foreign surface protein. This is a platform listing: products are typically 0.5 mL intramuscular doses of suspension, but each vaccine has its own composition and label.

The platform has been used for vaccines against Ebola virus disease and COVID-19, among others. Schedules differ: some products use one dose, others two, and some pair different vectors to sidestep immunity against the first. Pre-existing immunity to common human adenoviruses can blunt the response, so non-human and rare vectors are used. Regulators have added rare but serious adverse events to some adenovirus-vector labels, including thrombosis with thrombocytopenia syndrome, so current product information and national guidance govern use.

Sourcing notes. Vaccines are bought through national immunisation programmes, UN agencies or licensed importers, and each lot normally needs release by the national regulatory authority or control laboratory, based on the manufacturer's summary lot protocol. WHO prequalification, or Emergency Use Listing in emergencies, opens the way to UN-agency supply and supports national approval. Storage ranges from 2 to 8 °C to frozen or ultra-cold, so match your cold chain to the label. Request the CoA, lot release certificate and GMP certificate, and specify product, presentation and quantities.