Sitagliptin / Metformin XR Tablets bulk supplier for pharma manufacturers

Sitagliptin / Metformin Xr Tablets 100/1000 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100/1000 mg

Reference Brands: Janumet XR (US & EU)

Category: Diabetes

Sitagliptin inhibits DPP-4, prolonging incretin activity to enhance insulin secretion and suppress glucagon release. Metformin decreases hepatic glucose production and improves insulin sensitivity. The XR formulation ensures steady glucose control with reduced gastrointestinal side effects. Together, they offer synergistic action, improved glycemic control, and convenient once-daily dosing for Type 2 diabetes management.

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Product Description:

Sitagliptin + Metformin XR tablets, approved by the FDA (USA) and regulated by the EMA (EU), are indicated for the management of Type 2 diabetes when monotherapy fails. Brands like Janumet XR offer extended glycemic control with once-daily dosing. These tablets must meet stringent bioequivalence, GMP, and pharmacovigilance standards in both markets. EU guidelines require SmPC-compliant labeling and risk management plans. The combination enhances patient adherence and reduces glucose levels effectively. Pharmatradz.com, a global B2B pharmaceutical marketplace, connects buyers with trusted USFDA and EU-GMP certified manufacturers for bulk procurement of Sitagliptin + Metformin XR and other diabetes treatments.

Sitagliptin / Metformin Xr Tablets — third party manufacturing & bulk supply

Sitagliptin / Metformin Xr Tablets 100/1000 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Sitagliptin / Metformin Xr Tablets is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Sitagliptin / Metformin Xr Tablets listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Sitagliptin / Metformin XR tablets are used to manage blood sugar levels in patients with type 2 diabetes mellitus. This combination helps improve glycemic control when diet, exercise, or single therapy is not sufficient, and reduces the risk of long-term complications such as kidney damage, nerve problems, and cardiovascular issues.

These tablets are made from sitagliptin phosphate monohydrate and metformin hydrochloride (extended-release). Sitagliptin is a DPP-4 inhibitor that increases incretin levels to regulate insulin secretion, while metformin reduces glucose production in the liver and improves insulin sensitivity.

Common trade names include Janumet XR (USA), Velmetia (EU), Ristfor (EU), Istamet XR (India), and various generic brands available across global markets.

The original brand is developed and marketed by Merck & Co., Inc. (MSD). It is also manufactured by several global pharmaceutical companies including Sun Pharma, Cipla, Lupin, Dr. Reddy’s Laboratories, and other generic manufacturers.

The complete generic name is sitagliptin phosphate monohydrate and metformin hydrochloride extended-release tablets.

Brand names include Janumet XR, Velmetia, Ristfor, Istamet XR, and multiple region-specific generic brands.

These tablets are manufactured globally in countries such as the USA, UK, EU nations, India, and LATAM regions by both innovator and generic pharmaceutical companies.