Sitagliptin / Metformin Xr Tablets 100/1000 mg Suppliers & Bulk Manufacturers
Available Forms: Tablets
Available Strengths: 100/1000 mg
Reference Brands: Janumet XR (US & EU)
Category: Diabetes
Sitagliptin inhibits DPP-4, prolonging incretin activity to enhance insulin secretion and suppress glucagon release. Metformin decreases hepatic glucose production and improves insulin sensitivity. The XR formulation ensures steady glucose control with reduced gastrointestinal side effects. Together, they offer synergistic action, improved glycemic control, and convenient once-daily dosing for Type 2 diabetes management.
Product Description:
Sitagliptin + Metformin XR tablets, approved by the FDA (USA) and regulated by the EMA (EU), are indicated for the management of Type 2 diabetes when monotherapy fails. Brands like Janumet XR offer extended glycemic control with once-daily dosing. These tablets must meet stringent bioequivalence, GMP, and pharmacovigilance standards in both markets. EU guidelines require SmPC-compliant labeling and risk management plans. The combination enhances patient adherence and reduces glucose levels effectively. Pharmatradz.com, a global B2B pharmaceutical marketplace, connects buyers with trusted USFDA and EU-GMP certified manufacturers for bulk procurement of Sitagliptin + Metformin XR and other diabetes treatments.
Sitagliptin / Metformin Xr Tablets — third party manufacturing & bulk supply
Sitagliptin / Metformin Xr Tablets 100/1000 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Sitagliptin / Metformin Xr Tablets listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Sitagliptin / Metformin Xr Tablets →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Sitagliptin / Metformin XR tablets are used to manage blood sugar levels in patients with type 2 diabetes mellitus. This combination helps improve glycemic control when diet, exercise, or single therapy is not sufficient, and reduces the risk of long-term complications such as kidney damage, nerve problems, and cardiovascular issues.
These tablets are made from sitagliptin phosphate monohydrate and metformin hydrochloride (extended-release). Sitagliptin is a DPP-4 inhibitor that increases incretin levels to regulate insulin secretion, while metformin reduces glucose production in the liver and improves insulin sensitivity.
Common trade names include Janumet XR (USA), Velmetia (EU), Ristfor (EU), Istamet XR (India), and various generic brands available across global markets.
The original brand is developed and marketed by Merck & Co., Inc. (MSD). It is also manufactured by several global pharmaceutical companies including Sun Pharma, Cipla, Lupin, Dr. Reddy’s Laboratories, and other generic manufacturers.
The complete generic name is sitagliptin phosphate monohydrate and metformin hydrochloride extended-release tablets.
Brand names include Janumet XR, Velmetia, Ristfor, Istamet XR, and multiple region-specific generic brands.
These tablets are manufactured globally in countries such as the USA, UK, EU nations, India, and LATAM regions by both innovator and generic pharmaceutical companies.
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