Prothrombin Complex Concentrate (PCC) Injection 500 IU and 1,000 IU vials Suppliers & Bulk Manufacturers

Prothrombin Complex Concentrate (PCC) injection is used for the rapid treatment and prevention of bleeding caused by deficiencies of vitamin K-dependent clotting factors. It is commonly used to reverse the effects of warfarin or other vitamin K antagonist anticoagulants in cases of major bleeding or before urgent surgery.

Prothrombin Complex Concentrate injection is made from purified human plasma that contains a combination of vitamin K-dependent clotting factors, mainly factors II, VII, IX, and X.

Common trade names include Kcentra, Octaplex, Profilnine, Bebulin VH, and Cofact.

Prothrombin Complex Concentrate injections are manufactured by pharmaceutical companies such as CSL Behring, Octapharma, Pfizer, and Sanquin.

The generic name is prothrombin complex concentrate.

Brand names include Kcentra (USA), Octaplex (EU and international markets), Profilnine (USA), Bebulin VH (USA), and Cofact (Europe and Canada).

Prothrombin Complex Concentrate injection is manufactured in several countries including the United States, Germany, Austria, the Netherlands, and other European countries depending on the manufacturer.

4-factor PCC (such as Kcentra/Beriplex, Octaplex) contains factors II, VII, IX and X and is the standard for warfarin reversal. 3-factor PCC lacks meaningful factor VII and is used less often for this purpose.

Dosing is based on body weight and the starting INR, typically 25 to 50 IU/kg of factor IX, given with intravenous vitamin K.

As lyophilised powder at 2–25 °C, depending on the product. Each batch comes with an official control authority batch release certificate and plasma-origin documentation.