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Nefopam Hydrochloride bulk supplier for pharma manufacturers

Nefopam Hydrochloride Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 30 mg, 20 mg/2 mL

Reference Brands: Acupan (UK),

Category: Pain Management

Nefopam Hydrochloride is available in Tablet / Injection and strengths such as 30 mg, 20 mg/2 mL. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Nefopam Hydrochloride is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Technical Specifications & Supply Details
Lead Time 7 to 60 days (depending on batch size & schedule)
MOQ As per manufacturer’s batch size
COA Available with every batch
Regulatory Dossier / DMF Available upon request
Export Documentation FSC, COA, Manufacturing License, Product Permission
Standards IP, BP, USP
Certifications WHO-GMP, EU-GMP, USFDA (as applicable)

Nefopam Hydrochloride can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

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📘 Sourcing Guide

Product Description:

Nefopam hydrochloride is a benzoxazocine derivative classified as a non-opioid, non-steroidal, centrally acting analgesic. Developed in the 1960s and initially known as fenazocine, it was first investigated for its antidepressant properties before being recognized for its analgesic effects and subsequently renamed nefopam in 1970. Over time, it has gained clinical importance as an alternative option for pain management, particularly when opioid or NSAID therapy is not suitable.

Structurally, nefopam shows resemblance to antihistamines such as orphenadrine and diphenhydramine, although its pharmacological profile is distinct. The precise mechanisms underlying its analgesic action are complex and not yet fully understood. However, it is known to act centrally by modulating neurotransmitter pathways involved in pain perception, including inhibition of monoamine reuptake and modulation of excitatory neurotransmission.

Nefopam is commonly used for the management of moderate acute pain, postoperative pain, and certain chronic pain conditions. As it does not belong to the opioid or NSAID classes, it avoids many of the typical adverse effects associated with those groups, making it a valuable option in multimodal pain management strategies under appropriate medical supervision.

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Frequently Asked Questions

Nefopam hydrochloride is used for the relief of moderate to severe acute pain, including postoperative pain, traumatic pain, and acute musculoskeletal pain. It is often used as an alternative to opioid analgesics.

Nefopam is made from nefopam hydrochloride, a centrally acting benzoxazocine derivative that works by inhibiting the reuptake of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine.

The main trade name of nefopam hydrochloride in the UK is Acupan. In the EU and other regions, it may be marketed under different local brand names or as Nefopam.

In the UK, Acupan is marketed by companies holding national marketing authorization. In the EU, companies such as Mylan (now part of Viatris) have marketed Nefopam formulations depending on the country.

The generic name of Nefopam is nefopam hydrochloride.

The well-known brand name is Acupan in the UK. Other local brands are available depending on the country.

Nefopam hydrochloride is manufactured in various countries including the UK, France, India, and other regions depending on the marketing authorization holder and contract manufacturing arrangements.

Yes, Nefopam Hydrochloride is available with DMF and other regulatory documents such as COA and MSDS. These can be provided upon request for qualified buyers.

Absolutely. Sample requests are accepted for formulation trials and quality checks. Please submit an enquiry to initiate the process.

Our manufacturing partners are GMP-certified and comply with ISO and WHO standards, ensuring global quality benchmarks.

Lead times vary based on quantity and destination, but most orders are fulfilled within 1–3 weeks. Express shipping options are available.

Yes, Nefopam Hydrochloride is exported to over 30 countries across Asia, Africa, Europe, and Latin America. We support documentation for customs and regulatory clearance.

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