Nefopam Hydrochloride 30 mg, 20 mg/2 mL Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 30 mg, 20 mg/2 mL

Reference Brands: Acupan (UK),

Category: Pain Management

Nefopam Hydrochloride is a Pain Management product available as Tablet / Injection in strengths 30 mg, 20 mg/2 mL. It corresponds to the reference brands Acupan (UK),. Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Nefopam hydrochloride is a benzoxazocine derivative classified as a non-opioid, non-steroidal, centrally acting analgesic. Developed in the 1960s and initially known as fenazocine, it was first investigated for its antidepressant properties before being recognized for its analgesic effects and subsequently renamed nefopam in 1970. Over time, it has gained clinical importance as an alternative option for pain management, particularly when opioid or NSAID therapy is not suitable.

Structurally, nefopam shows resemblance to antihistamines such as orphenadrine and diphenhydramine, although its pharmacological profile is distinct. The precise mechanisms underlying its analgesic action are complex and not yet fully understood. However, it is known to act centrally by modulating neurotransmitter pathways involved in pain perception, including inhibition of monoamine reuptake and modulation of excitatory neurotransmission.

Nefopam is commonly used for the management of moderate acute pain, postoperative pain, and certain chronic pain conditions. As it does not belong to the opioid or NSAID classes, it avoids many of the typical adverse effects associated with those groups, making it a valuable option in multimodal pain management strategies under appropriate medical supervision.