Leucovorin Calcium Tablets bulk supplier for pharma manufacturers

Leucovorin Calcium Tablets 5 mg, 10 mg, 15 mg, 25 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 5 mg, 10 mg, 15 mg, 25 mg

Reference Brands: Generic leucovorin calcium (originator brand Wellcovorin)

Leucovorin calcium (folinic acid) tablets, 5 mg to 25 mg, are mainly used as "leucovorin rescue" after high-dose methotrexate and to counter overdose of folic acid antagonists. Leucovorin is off patent and made by several manufacturers in the US, Europe and India. We quote from GMP-approved manufacturers and confirm document status, lead time and MOQ for each order.

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Product Description:

Leucovorin (folinic acid) is a reduced form of folic acid. Unlike folic acid, it does not need the enzyme dihydrofolate reductase to become active, so it can supply folate to cells even when that enzyme is blocked by drugs such as methotrexate, pyrimethamine or trimethoprim.

Leucovorin calcium tablets (5, 10, 15 and 25 mg) are used for leucovorin rescue after high-dose methotrexate, started at a set time after the methotrexate dose and adjusted to blood methotrexate levels, and to treat overdose or toxicity of folic acid antagonists. The injection form, which is listed separately, is also used with fluorouracil in colorectal cancer and for megaloblastic anaemia when oral treatment is not possible. Leucovorin must not be confused with folic acid (for example Folvite), which is a different product.

Sourcing notes. Leucovorin calcium is off patent. Tablets and injections are made by generic manufacturers in the US, Europe and India, and the API is widely available. Levoleucovorin, the active isomer, is listed separately. We confirm the manufacturer, registration documents and lead time for your market.

Leucovorin Calcium Tablets — third party manufacturing & bulk supply

Leucovorin Calcium Tablets 5 mg, 10 mg, 15 mg, 25 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Leucovorin Calcium Tablets is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Leucovorin Calcium Tablets listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Leucovorin calcium is off patent and made by several generic manufacturers in the US, Europe and India. We source tablets, injection and API from GMP-approved makers.

Mainly leucovorin rescue after high-dose methotrexate and treatment of folic acid antagonist toxicity.

No. Leucovorin (folinic acid) is already in the active form and works even when methotrexate blocks folate activation.

5 mg, 10 mg, 15 mg and 25 mg tablets.

In September 2025 the US FDA said it had started the process of approving leucovorin calcium tablets for cerebral folate deficiency (CFD), a rare condition in which folate is not transported into the brain normally. In March 2026 it approved GSK's Wellcovorin tablets for CFD in patients with a confirmed variant in the folate receptor 1 (FOLR1) gene. These announcements greatly increased interest in leucovorin. Prescribing remains a decision for doctors, and we supply licensed buyers only.