Imlunestrant Tosylate 200 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 200 mg

Reference Brands: Inluriyo (USA)

Category: Oncology Cancer Care

Imlunestrant is an oral selective estrogen receptor degrader (SERD) that binds to estrogen receptors, including mutant ESR1 forms, leading to receptor degradation and blocking estrogen-driven signaling in breast cancer cells. It is approved for adults with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer who have progressed on prior endocrine therapy. The recommended dose is once daily, taken on an empty stomach. It helps slow tumor progression, and common side effects include fatigue, diarrhea, musculoskeletal pain, and liver enzyme elevations.

Product Description:

Imlunestrant is an oral selective estrogen receptor degrader. Its purpose is to solve a specific resistance problem: after prolonged aromatase inhibitor treatment, breast cancers commonly acquire mutations in the ESR1 gene that lock the receptor into an active shape which no longer needs oestrogen at all. Lowering oestrogen further achieves nothing in that situation. A degrader binds the receptor, mutant form included, and directs it for destruction.

It is indicated for adults with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer that has progressed on prior endocrine therapy, taken once daily on an empty stomach. Its advantage over the injectable degrader that preceded it is straightforward: a tablet replaces monthly intramuscular injections and achieves more complete receptor degradation. Fatigue, diarrhoea, nausea, musculoskeletal pain and transaminase elevation are the common adverse effects, and liver function requires monitoring.

Sourcing notes. Recently approved originator product, on patent, with approval so far limited to a small number of territories — confirm registration before quoting. Requires ESR1 mutation testing, usually on circulating tumour DNA from a blood sample, so the destination market needs that assay available. Oral tablet, room temperature.