Hydrochlorothiazide Tablets 12.5 mg, 25 mg, 50 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 12.5 mg, 25 mg, 50 mg

Reference Brands: HydroDiuril (US)

Category: Medical Aid

Hydrochlorothiazide tablets 12.5 mg, 25 mg and 50 mg, a thiazide diuretic for hypertension and oedema, for importers, distributors, hospitals and tender buyers sourcing a long-established generic.

Product Description:

Hydrochlorothiazide is a thiazide diuretic. It blocks sodium and chloride reabsorption in the distal tubule of the kidney, so more salt and water leave in the urine. Over weeks it also relaxes blood vessels, which is why it controls blood pressure at doses too small to cause much diuresis. This page covers plain tablets of 12.5 mg, 25 mg and 50 mg. The two lower strengths match current antihypertensive practice, while 50 mg is mainly used for oedema.

Approved uses are hypertension, alone or combined, and oedema from heart failure, liver or kidney disease. It is a frequent partner for ACE inhibitors, angiotensin receptor blockers and beta blockers. It is taken once daily in the morning to avoid night-time urination. Pharmacists check sodium, potassium and renal function, as hypokalaemia and hyponatraemia are the main risks. It can raise uric acid, blood glucose and lithium levels. Long-term use has been linked to non-melanoma skin cancer, so sun protection advice belongs on the leaflet.

Sourcing notes. Hydrochlorothiazide tablets are prescription-only in most markets and registered through a CTD or ACTD dossier with bioequivalence data, or a biowaiver where accepted. Ask for the pharmacopoeial monograph followed, the impurity profile and the API DMF or CEP reference. Score lines matter if the 25 mg or 50 mg tablet will be halved. Ask for zone IVb data for hot humid markets and confirm the blister material. Documents to request are a batch CoA, the GMP certificate and a CoPP. In your enquiry, state strengths, pack size and whether you need a scored tablet.