Etoposide Suppliers & Bulk Manufacturers

Available Forms: Oral Capsules & Injection:

Available Strengths: Injection: 20 mg/mL; Capsule: 50 mg

Reference Brands: US: VePesid® (capsules); EU: Etopophos® (injectable phosphate form) Vepesid® (capsules)

Category: Oncology Cancer Care

Etoposide 20 mg/mL concentrate for infusion and 50 mg soft capsules, a topoisomerase II inhibitor used in combination chemotherapy. Offered to hospital oncology pharmacies, cancer centres, importers and tender buyers.

Product Description:

Etoposide is a semi-synthetic derivative of podophyllotoxin, a plant compound. It inhibits topoisomerase II, the enzyme that cuts and rejoins DNA, leaving breaks that kill dividing cancer cells. This page covers two forms. The 20 mg/mL concentrate is diluted for intravenous infusion and is used in most hospital combination chemotherapy. The 50 mg soft capsule lets selected patients take treatment by mouth, for example in palliative schedules. Oral bioavailability is roughly half, so an oral dose is about twice the intravenous one.

Etoposide is part of standard regimens for small cell lung cancer and testicular germ cell tumours, and is used in lymphomas, acute myeloid leukaemia and several childhood cancers. WHO includes it on its Model List of Essential Medicines. The concentrate is diluted, typically to no more than 0.4 mg/mL, to avoid precipitation, and infused over at least 30 minutes, since fast infusion causes hypotension. Undiluted concentrate can crack acrylic or ABS plastic devices. Myelosuppression is dose-limiting, and secondary leukaemia is a recognised late risk.

Sourcing notes. Both forms are prescription-only cytotoxic medicines, registered nationally in CTD or ACTD format from sites approved for cytotoxics. The concentrate contains solubilisers such as polysorbate 80, macrogol and ethanol, so compare excipients with the reference product. Vials are stored at room temperature away from light. Capsule storage differs between products, and some labels ask for refrigeration, so confirm before agreeing transport. Ask for a batch CoA, GMP certificate, CoPP and IVb stability. Quote form, strength, vial volume and pack count.

Also known as: etopósido (Spanish), etoposídeo (Portuguese), étoposide (French), Etoposid (German), etoposide (Italian, Vietnamese), etoposid (Turkish), etoposida (Indonesian), этопозид (Russian), إيتوبوسيد (Arabic), 依托泊苷 (Chinese), エトポシド (Japanese), 에토포시드 (Korean).