Esketamine 28 mg Suppliers & Bulk Manufacturers
Available Forms: Nasal spray
Available Strengths: 28 mg
Reference Brands: Spravato (USA/EU)
Category: Psychiatry / Mental Health
Esketamine is a Psychiatry / Mental Health product available as Nasal spray in strengths 28 mg. It corresponds to the reference brand Spravato (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.
Product Description:
Esketamine nasal spray is a novel antidepressant specifically indicated for treatment-resistant depression (TRD) in adults. It provides a rapid-acting option for patients with major depressive disorder (MDD) who have not responded adequately to conventional antidepressant therapies. Esketamine is the S-enantiomer of ketamine and acts as an NMDA receptor antagonist, modulating glutamatergic neurotransmission in the brain to improve mood and cognitive function.
Major depressive disorder is a widespread mental health condition affecting millions globally, characterized by persistent low mood, loss of interest or pleasure in daily activities, and associated symptoms such as fatigue, weight changes, psychomotor retardation, feelings of worthlessness, impaired concentration, and suicidal thoughts. Esketamine offers a valuable therapeutic approach for patients with severe or refractory depression, providing benefits in both symptom relief and functional improvement. Administered intranasally under medical supervision, it is generally well-tolerated, though monitoring for potential adverse effects, including dissociation and blood pressure changes, is recommended. Esketamine represents an important advancement in the management of MDD, particularly for patients with limited response to traditional antidepressants.
Esketamine — third party manufacturing & bulk supply
Esketamine 28 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Esketamine listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Esketamine →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Esketamine nasal spray is used to treat adults with treatment‑resistant depression (TRD) and, in some regions, depressive symptoms in adults with major depressive disorder (MDD) who have suicidal ideation or behavior. It is designed to produce rapid antidepressant effects when other therapies have been inadequate.
Esketamine is made from the active pharmaceutical ingredient esketamine, the S‑enantiomer of ketamine. It acts as an NMDA receptor antagonist in the brain, modulating glutamatergic neurotransmission to improve depressive symptoms.
The widely recognized trade name of esketamine nasal spray is Spravato.
Esketamine (Spravato) is manufactured and marketed by Johnson & Johnson (Janssen Pharmaceuticals) in many global markets through authorized pharmaceutical partners.
The generic name is esketamine.
The most recognized brand name is Spravato.
Esketamine nasal spray is manufactured in regulated pharmaceutical facilities that comply with international quality standards, including sites in the United States and other approved regions.
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