Dexrazoxane Hydrochloride 500 mg/50 mL, 250 mg/25 mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 500 mg/50 mL, 250 mg/25 mL

Reference Brands: Zinecard (USA), Totect (USA), Cardioxane (EU)

Category: Oncology Cancer Care

Dexrazoxane Hydrochloride is a Oncology Cancer Care product available as Injection in strengths 500 mg/50 mL, 250 mg/25 mL. It corresponds to the reference brands Zinecard (USA), Totect (USA), Cardioxane (EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Dexrazoxane hydrochloride is a cardioprotective agent used in oncology to minimize the risk of heart damage caused by anthracycline chemotherapy, such as doxorubicin and daunorubicin. Discovered in 1972, it is administered intravenously under acidic conditions, with hydrochloric acid used to adjust the solution’s pH for stability and efficacy. Dexrazoxane works by chelating iron and preventing the formation of free radicals, which are responsible for chemotherapy-induced cardiotoxicity.

Initially, regulatory restrictions limited its use in pediatric patients due to concerns over secondary malignancies and acute myeloid leukemia when used alongside anthracyclines. However, updated guidance from the European Medicines Agency and European Commission has allowed dexrazoxane to be used for primary prevention of anthracycline-induced cardiotoxicity in children and adolescents under carefully monitored conditions.

Dexrazoxane hydrochloride is also used as an antidote for anthracycline extravasation, reducing tissue injury at the site of accidental drug leakage. It is available under brand names such as Zinecard and Cardioxane, and is supplied as an injectable solution for intravenous administration, providing effective cardioprotection while allowing patients to continue life-saving chemotherapy regimens.