Dexrazoxane Hydrochloride bulk supplier for pharma manufacturers

Dexrazoxane Hydrochloride 500 mg/50 mL, 250 mg/25 mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 500 mg/50 mL, 250 mg/25 mL

Reference Brands: Zinecard (USA), Totect (USA), Cardioxane (EU)

Dexrazoxane Hydrochloride is a Oncology Cancer Care product available as Injection in strengths 500 mg/50 mL, 250 mg/25 mL. It corresponds to the reference brands Zinecard (USA), Totect (USA), Cardioxane (EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

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Product Description:

Dexrazoxane hydrochloride is a cardioprotective agent used in oncology to minimize the risk of heart damage caused by anthracycline chemotherapy, such as doxorubicin and daunorubicin. Discovered in 1972, it is administered intravenously under acidic conditions, with hydrochloric acid used to adjust the solution’s pH for stability and efficacy. Dexrazoxane works by chelating iron and preventing the formation of free radicals, which are responsible for chemotherapy-induced cardiotoxicity.

Initially, regulatory restrictions limited its use in pediatric patients due to concerns over secondary malignancies and acute myeloid leukemia when used alongside anthracyclines. However, updated guidance from the European Medicines Agency and European Commission has allowed dexrazoxane to be used for primary prevention of anthracycline-induced cardiotoxicity in children and adolescents under carefully monitored conditions.

Dexrazoxane hydrochloride is also used as an antidote for anthracycline extravasation, reducing tissue injury at the site of accidental drug leakage. It is available under brand names such as Zinecard and Cardioxane, and is supplied as an injectable solution for intravenous administration, providing effective cardioprotection while allowing patients to continue life-saving chemotherapy regimens.

Dexrazoxane Hydrochloride — third party manufacturing & bulk supply

Dexrazoxane Hydrochloride 500 mg/50 mL, 250 mg/25 mL is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Dexrazoxane Hydrochloride is supplied as Injection — an injectable dosage form, so the indicative MOQ is 50,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Dexrazoxane Hydrochloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Dexrazoxane hydrochloride is used as a cardioprotective agent to reduce the risk of heart damage caused by anthracycline chemotherapy. It is also used as an antidote to treat tissue injury caused by anthracycline extravasation.

Dexrazoxane hydrochloride is a synthetic iron-chelating compound formulated as a sterile injectable solution for intravenous administration.

Common trade names include Zinecard, Totect, and Cardioxane.

Dexrazoxane hydrochloride is manufactured and marketed by multiple pharmaceutical companies, including Novartis and Teva Pharmaceuticals, depending on the brand.

The generic name is dexrazoxane hydrochloride.

Brand names include Zinecard, Totect, and Cardioxane.

Dexrazoxane hydrochloride is manufactured under the specifications of the respective marketing authorization holders in compliance with international pharmaceutical manufacturing standards.