Deferasirox Tablets 125 mg, 250 mg, and 500 mg Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 125 mg, 250 mg, and 500 mg

Reference Brands: Exjade(Dispersible tablets);Jadenu (Film-coated Tablet)s

Category: Blood Disorder

Deferasirox 125 mg, 250 mg and 500 mg dispersible tablets, an oral iron chelator for transfusional iron overload, for importers, distributors, haematology units and thalassaemia programmes.

Product Description:

Deferasirox is an oral iron chelator: two molecules bind one iron atom in a stable complex excreted mainly in the faeces. The 125 mg, 250 mg and 500 mg strengths on this page belong to the dispersible tablet, stirred into water, orange juice or apple juice and drunk at once. A later film-coated tablet uses different strengths at lower doses because exposure is higher. The forms are not interchangeable milligram for milligram. The dispersible form suits children and anyone who cannot swallow tablets.

It is used for chronic iron overload from repeated transfusions, as in beta-thalassaemia major and sickle cell disease, and in some labels for non-transfusion-dependent thalassaemia. It is taken once daily by weight, on an empty stomach at least 30 minutes before food. Serum ferritin is checked monthly to guide dosing. Kidney, liver and blood tests are monitored because renal and hepatic impairment and gastrointestinal bleeding can occur, and hearing and eyes are checked. Aluminium antacids are avoided, and rifampicin reduces exposure.

Sourcing notes. Deferasirox is prescription-only, and each form needs its own bioequivalence data and dossier, so state dispersible or film-coated in your enquiry. Ask for the CTD or ACTD file with dissolution and dispersion-time data and zone IVb stability for hot, humid markets. Blisters are kept at room temperature, away from moisture. Request a CoA per batch with assay, impurity and dispersion results, the GMP certificate and a CoPP. Thalassaemia programmes order for months ahead, so state pack size and remaining shelf life.