Colistimethate (Colistin) bulk supplier for pharma manufacturers

Colistimethate (Colistin) Suppliers & Bulk Manufacturers

Available Forms: Intravenous (IV) Injection

Available Strengths: 1 MIU, 2 MIU vials; 150 mg colistin base activity (about 4.5 MIU) per vial

Reference Brands: Coly-Mycin M(US); Colomycin(EU)

Colistimethate sodium powder for injection or nebulisation, a polymyxin Reserve antibiotic for multidrug-resistant Gram-negative infections. For hospitals, ICUs, tender buyers and licensed importers.

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Product Description:

Colistimethate sodium is an inactive prodrug converted in the body to colistin, a polymyxin antibiotic. Colistin binds lipopolysaccharide in the outer membrane of Gram-negative bacteria and breaks it open, killing organisms such as Pseudomonas aeruginosa, Acinetobacter baumannii and many Enterobacterales. It has no useful activity against Gram-positive bacteria, Proteus or Serratia. It is a sterile powder in single-dose vials, used by intravenous injection or infusion and, in many markets, by nebuliser.

WHO places colistin in the Reserve group of its AWaRe classification, for multidrug-resistant infections when other options have failed. Strength labelling is a known source of error: European vials state million international units, where 1 million IU is about 33 mg colistin base activity, while US vials state milligrams of colistin base activity. A 150 mg base activity vial thus holds about 4.5 million IU. Dosing uses a loading dose and is adjusted for kidney function. Nephrotoxicity and neurotoxicity are the main risks, and it can deepen neuromuscular blockade.

Sourcing notes. In tenders and orders, state strength as both IU and mg colistin base activity, and check every batch label so that pharmacists and prescribers do not mix up units. Vials are stored at room temperature; reconstituted solution is used promptly, as the label directs. Confirm whether the vial is licensed for intravenous use, inhalation or both. Ask for a CoA per batch with potency, sterility and endotoxin results, a GMP certificate and CoPP, and zone IVb stability data for hot, humid markets. It is a prescription-only antibiotic, often released under hospital stewardship approval.

Colistimethate (Colistin) — third party manufacturing & bulk supply

Colistimethate (Colistin) is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Colistimethate (Colistin) is supplied as Intravenous (IV) Injection — an injectable dosage form, so the indicative MOQ is 50,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Colistimethate (Colistin) listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Colistimethate (Colistin) is listed as Intravenous (IV) Injection in 1 MIU, 2 MIU vials; 150 mg colistin base activity (about 4.5 MIU) per vial. Further strengths and pack presentations are confirmed with the manufacturer at RFQ stage.

Colistimethate (Colistin) is referenced against Coly-Mycin M(US); Colomycin(EU). Reference brands are shown for identification only and remain the property of their respective trademark owners.