Carmustine 100 mg Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 100 mg

Reference Brands: BiCNU (USA), Gliadel (USA)

Category: Oncology Cancer Care

Carmustine is a Oncology Cancer Care product available as Injection in strengths 100 mg. It corresponds to the reference brands BiCNU (USA), Gliadel (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Carmustine is a chemotherapeutic medication sold under the brand name BiCNU and other regional brands, primarily used as an alkylating agent in cancer treatment. Chemically classified as a nitrogen mustard β-chloro-nitrosourea compound, carmustine works by forming cross-links in DNA, preventing cancer cells from dividing and promoting cell death. It is widely used to treat various cancers, including brain tumors such as glioma, glioblastoma multiforme, medulloblastoma, and astrocytoma, as well as multiple myeloma, Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma.

Carmustine is often used in combination with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine, which enhance its efficacy by blocking DNA repair pathways and increasing cancer cell sensitivity. Additionally, it is used as part of pre-transplant conditioning protocols in hematological stem cell transplantation, typically alongside fludarabine and melphalan, to reduce white blood cell counts and prepare patients for bone marrow transplant procedures.

For the treatment of brain tumors, carmustine is also available in biodegradable implantable wafers, marketed as Gliadel, which are placed under the skull during craniotomy. These implants provide controlled local release of the drug directly into the brain tissue, bypassing the blood-brain barrier and maximizing therapeutic effect while minimizing systemic exposure. Carmustine remains an essential tool in oncology for both systemic and localized cancer therapy.