Apremilast 10 mg, 20 mg, 30 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10 mg, 20 mg, 30 mg

Reference Brands: Otezla(USA)

Category: Immune Disorder

Apremilast is a Immune Disorder product available as Tablets in strengths 10 mg, 20 mg, 30 mg. It corresponds to the reference brand Otezla(USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Apremilast, marketed under the brand name Otezla, is an FDA-approved small-molecule phosphodiesterase 4 (PDE4) inhibitor used for the treatment of several immune-mediated conditions. It is indicated for adults with moderately to severely active psoriatic arthritis, plaque psoriasis who are candidates for phototherapy or systemic therapy, and Behçet’s disease associated with oral ulcers. By inhibiting PDE4, apremilast increases intracellular cyclic adenosine monophosphate (cAMP) levels, which helps modulate inflammatory pathways and reduce the production of pro-inflammatory cytokines such as TNF-α, IL-17, and IL-23, thereby decreasing inflammation and immune-mediated tissue damage.

Apremilast is administered orally as a convenient tablet formulation and is generally well-tolerated. Common side effects include gastrointestinal symptoms, headache, and weight loss, while rare but serious adverse events may occur, requiring careful patient monitoring. In addition to its approved indications, apremilast is sometimes used off-label for dermatologic disorders unresponsive to conventional therapies such as systemic corticosteroids or immunosuppressive agents. Its mechanism of action and safety profile make it a valuable option for interprofessional management of patients with moderate to severe psoriatic arthritis, plaque psoriasis, and Behçet’s disease.