Abaloparatide Suppliers & Bulk Manufacturers

Available Forms: injection (prefilled syringe)

Available Strengths: 80 mcg

Reference Brands: Tymlos (USA), Eladynos (EU)

Category: Osteoporosis

Product Description:

Abaloparatide is a synthetic analog of human parathyroid hormone–related peptide (PTHrP 1–34) developed for the treatment of osteoporosis, particularly in postmenopausal women who are at high risk of fractures. The amino-acid sequence of abaloparatide is identical to PTHrP in the first 20 amino acids, while several differences in the remaining sequence contribute to its unique pharmacological profile. This modification allows abaloparatide to stimulate bone formation effectively while producing relatively lower stimulation of bone resorption compared with some earlier anabolic therapies.

Abaloparatide works by activating the PTH1 receptor in bone tissue, promoting new bone formation and increasing bone mineral density (BMD). Its mechanism is associated with a more transient signaling response, which may contribute to its strong anabolic effect on bone. Clinical studies, including large phase 3 trials in postmenopausal women with osteoporosis, have shown that abaloparatide significantly reduces the risk of vertebral and non-vertebral fractures while improving bone density at important skeletal sites such as the lumbar spine, hip, and femoral neck.

Administered as a once-daily subcutaneous injection, abaloparatide represents an important anabolic treatment option for osteoporosis. It offers a promising approach for patients requiring therapies that actively build bone and help reduce fracture risk.