Pancreatin Capsule 25000 IU Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 25000 IU

Reference Brands:

Category: Nutraceuticals

Pancreatin 25,000-unit capsules with enteric-coated pellets for exocrine pancreatic insufficiency. For importers, distributors, hospital pharmacies and cystic fibrosis and gastroenterology services.

Product Description:

This page covers pancreatin hard capsules labelled 25,000 units, which by convention means lipase activity in Ph. Eur. units rather than international units; each capsule also states protease and amylase content. Pancreatin is an extract of pig pancreas. In capsules, the enzymes sit as enteric-coated minimicrospheres or minitablets in a gelatin shell, released once the pH rises in the duodenum. The pellets can be sprinkled on soft acidic food for infants and people who cannot swallow capsules, so this form is widely used in cystic fibrosis clinics.

Pancreatin capsules are prescribed for exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy or pancreatic cancer. Doses go with meals and snacks, adjusted to fat content, body weight and stool pattern. Capsules should not be crushed or chewed, and opened contents must not be held in the mouth. Very high doses in cystic fibrosis have been associated with fibrosing colonopathy, so guidelines cap daily lipase per kilogram. Hypersensitivity to porcine protein is a contraindication.

Sourcing notes. In most regulated markets a 25,000-unit capsule is a prescription or pharmacy medicine, although some countries list enzyme products as supplements, so confirm the category first. Check whether the label uses Ph. Eur. or USP units, since protease and amylase units differ between them. Lipase activity declines in heat and humidity; request stability data at destination conditions, zone IVb included, and the overage policy. Request a CoA per batch with enzyme assays, coating acid-resistance and microbial limits, the GMP certificate, a CoPP and porcine source documents.