Liposomal Amphotericin B Injectable bulk supplier for pharma manufacturers

Liposomal Amphotericin B Injectable 50 mg/vial Suppliers & Bulk Manufacturers

Q: How is liposomal amphotericin B stored?

Unopened AmBisome vials are stored at up to 25 Â°C. Generic products may have different storage conditions, so always check the labelling of the product you are buying.

Available Forms: Injection

Available Strengths: 50 mg/vial

Reference Brands: AmBisome(US & EU)

Category: Anti-fungal

Liposomal Amphotericin B binds to fungal ergosterol, creating pores that disrupt cell membrane integrity and cause fungal cell death. It offers broad-spectrum activity, enhanced tissue penetration, and reduced toxicity compared to conventional formulations. Benefits include effective treatment of severe systemic infections with fewer side effects, improving patient outcomes.

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Product Description:

Liposomal amphotericin B is amphotericin B built into the membrane of small lipid vesicles called liposomes. The formulation keeps the strong antifungal effect of amphotericin B while causing much less kidney toxicity and fewer infusion reactions than the conventional deoxycholate form. It is used, depending on the approved indications in each country, for invasive fungal infections such as aspergillosis, mucormycosis, cryptococcal meningitis and systemic candidiasis, for visceral leishmaniasis, and as empirical therapy in febrile neutropenic patients. The originator is Gilead's AmBisome, supplied as a 50 mg vial of lyophilised powder.

Liposomal amphotericin B manufacturing in India

Several Indian manufacturers make liposomal amphotericin B. Indian production was scaled up sharply in 2021, when a surge of mucormycosis, often called "black fungus", among COVID-19 patients caused shortages. Indian products are sold domestically and supplied to export and tender markets, and at least one Indian manufacturer has received US FDA approval for a generic version.

Not all amphotericin B products are the same

Amphotericin B comes in formulations that are not interchangeable: conventional amphotericin B deoxycholate, amphotericin B lipid complex (Abelcet) and liposomal amphotericin B. Doses differ between them. Even among liposomal products, liposome size, lipid composition and the manufacturing process affect how the drug behaves, which is why regulators such as the US FDA ask generic makers for detailed physicochemical and pharmacokinetic comparisons with AmBisome. When you source, ask for:

the reference product the generic was compared with, and the regulator that approved it;
registration status in the country of manufacture and in your market;
the site's sterile manufacturing (GMP) certificate and a recent Certificate of Analysis;
labelled storage conditions and remaining shelf life.

Conventional amphotericin B injection is listed separately. For hospital and government tenders, see our tender supply service, or send us an RFQ with the quantity and destination market.

Liposomal Amphotericin B Injectable — third party manufacturing & bulk supply

Liposomal Amphotericin B Injectable 50 mg/vial is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Liposomal Amphotericin B Injectable is supplied as Injection — an injectable dosage form, so the indicative MOQ is 50,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Liposomal Amphotericin B Injectable listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Serious invasive fungal infections such as aspergillosis, mucormycosis, cryptococcal meningitis and systemic candidiasis, visceral leishmaniasis, and empirical treatment of suspected fungal infection in febrile neutropenic patients. Approved indications vary by country and product.

Several Indian manufacturers produce it for the Indian market, for export and for tenders. We match each enquiry with manufacturers whose registrations and documents fit the destination market.

No. Liposomal amphotericin B (AmBisome and its generics) and amphotericin B lipid complex (Abelcet) are different formulations with different doses. Neither should be substituted for the other, or for conventional amphotericin B, without a prescriber's decision.

The originator brand is AmBisome, from Gilead. Generic versions are sold under other brand names in India and other markets.

Unopened AmBisome vials are stored at up to 25 °C. Generic products may have different storage conditions, so always check the labelling of the product you are buying.