Gadoversetamide Injectable Solution 0.5 mol/L Suppliers & Bulk Manufacturers

Available Forms: Injectable Solution

Available Strengths: 0.5 mol/L

Reference Brands: OptiMARK(US & EU)

Category: Contrast Agent

Gadoversetamide 0.5 mmol/mL, a linear gadolinium MRI contrast agent now withdrawn from major markets. For radiology buyers checking remaining registrations or choosing a currently registered alternative.

Product Description:

Gadoversetamide is a linear, non-ionic gadolinium-based MRI contrast agent formulated at 0.5 mmol/mL. The gadolinium ion shortens T1 relaxation in the tissues it reaches, brightening areas where the blood-brain barrier has broken down or vessels are abnormal. It is an extracellular agent: it spreads through plasma and interstitial fluid and is excreted unchanged by the kidneys. Its open-chain chelate holds gadolinium less tightly than the macrocyclic agents now used in most departments.

It was used for MRI of the brain and spine and for liver imaging. Regulators placed it among the agents with the highest risk of nephrogenic systemic fibrosis, and later reviews of gadolinium retention in the brain and other tissues went against linear agents of this type. It has since been withdrawn from major markets, including the European Union and the United States, and imaging departments there use other agents. Where any registration remains, it is contraindicated in severe chronic kidney disease and acute kidney injury.

Sourcing notes. Supply depends entirely on whatever registrations remain, and stock is rarely available, so most buyers searching for it will need an alternative chosen by their radiologists. If an offer appears, ask for proof of current registration in the country of sale, the batch CoA, GMP certificate and CoPP, and check the expiry date with care, since old stock is a real risk with discontinued contrast media. Never accept relabelled or repacked product. For a tender, describe the imaging need rather than naming this agent, so suppliers can offer a currently registered product.