Diacerein, Glucosamine Sulphate & Methyl sulfonyl methane Tablets bulk supplier for pharma manufacturers

Diacerein, Glucosamine Sulphate & Methyl Sulfonyl Methane Tablets Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: -

Reference Brands: -

Category: Arthritis

Diacerein, glucosamine sulphate and methylsulfonylmethane tablets, a fixed combination prescribed for osteoarthritis symptoms in some markets. For licensed importers, orthopaedic distributors and pharmacies.

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Product Description:

This tablet combines three ingredients aimed at osteoarthritis. Diacerein is an anthraquinone whose active metabolite, rhein, inhibits interleukin-1 beta, a cytokine involved in cartilage breakdown; its effect takes weeks to appear. Glucosamine sulphate is an amino sugar used in cartilage glycosaminoglycans. Methylsulfonylmethane is an organic sulfur compound sold widely as a joint supplement. Formulas vary, so ask for the content of each ingredient per tablet. The combination is registered in a limited number of markets.

It is prescribed for symptomatic osteoarthritis of the hip and knee. Evidence for glucosamine and MSM is mixed, and well-conducted trials have often found little benefit. Diacerein carries most of the risk. The EMA restricted it after review: not recommended from age 65, started at a reduced dose because diarrhoea is very common, stopped if diarrhoea develops, and avoided in liver disease. It colours urine yellow to red. Glucosamine is often made from shellfish, and it may raise the INR in patients on warfarin.

Sourcing notes. Confirm first that your regulator accepts this fixed combination, and ask for the dossier's rationale for combining three actives. Specify the glucosamine salt and its source, shellfish or non-animal fermentation, since this drives allergen labelling. Ask for a CoA per batch with assay of all three ingredients, dissolution and related substances, including control of aloe-emodin in the diacerein. Glucosamine salts take up moisture, so alu-alu blisters and zone IVb stability data matter. Request the GMP certificate and a CoPP. Diacerein makes it prescription-only.

Diacerein, Glucosamine Sulphate & Methyl Sulfonyl Methane Tablets — third party manufacturing & bulk supply

Diacerein, Glucosamine Sulphate & Methyl Sulfonyl Methane Tablets is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Diacerein, Glucosamine Sulphate & Methyl Sulfonyl Methane Tablets is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Diacerein, Glucosamine Sulphate & Methyl Sulfonyl Methane Tablets listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Diacerein, Glucosamine Sulphate & Methyl sulfonyl methane Tablets is listed as Tablets in -. Further strengths and pack presentations are confirmed with the manufacturer at RFQ stage.

Diacerein, Glucosamine Sulphate & Methyl sulfonyl methane Tablets is referenced against -. Reference brands are shown for identification only and remain the property of their respective trademark owners.