Clotrimazole Vaginal Tablets/Cream Suppliers & Bulk Manufacturers

Available Forms: Vaginal Tablets/Cream

Available Strengths: 100 mg, 200 mg (vaginal tablets); 1% (cream)

Reference Brands: Canesten (EU), Gyne-Lotrimin (US)

Category: Anti-fungal

Clotrimazole 100 mg and 200 mg vaginal tablets and 1% cream, a local imidazole antifungal for vaginal yeast infection. For importers, distributors, pharmacy chains and women's health programmes.

Product Description:

Clotrimazole is an imidazole antifungal. It blocks the fungal enzyme lanosterol 14-alpha-demethylase, so the yeast cannot make ergosterol and its cell membrane becomes leaky. Used in the vagina it acts locally, and very little reaches the bloodstream. This page covers vaginal tablets, or pessaries, of 100 mg and 200 mg, and a 1% cream. The pessary puts a high dose exactly where Candida grows, allowing short courses, while the cream is applied to the vulva for itching and soreness.

The main use is vulvovaginal candidiasis, or thrush. A vaginal tablet is inserted high into the vagina at bedtime, usually with the applicator provided, and course length depends on strength. In pregnancy, labels advise care with the applicator. Local burning or irritation can occur. Clotrimazole can damage latex condoms and diaphragms, so barrier contraception may fail during use. First episodes, frequent recurrences, fever or abnormal bleeding call for a doctor, as other infections can look similar.

Sourcing notes. Status differs by market: some sell these products over the counter in pharmacies, others keep them on prescription. Ask for a CTD or ACTD dossier and zone IVb stability data. Vaginal tablets are moisture-sensitive and usually sealed in aluminium blisters with an applicator in the carton; the cream comes in aluminium or laminate tubes, so check the lining and closure. Ask for a certificate of analysis on every lot, along with GMP and CoPP documents. Say which strengths you want, whether you need combined pessary and cream packs, and the label language.