Antithymocyte Immunoglobulins Injection 25mg, 100 mg, 500 mg Suppliers & Bulk Manufacturers
Available Forms: Injection
Available Strengths: 25mg, 100 mg, 500 mg
Reference Brands: Thymoglobulin (USA/EU/LATAM), Fresenius ATG (EU)
Category: Transplant
This injection is a purified and sterile form of gamma globulin. It is isolated from the hyperimmune plasma of horses immunized with human white blood cell components. It is used after kidney transplantation along with other therapies to treat as well as delay organ rejection.
Product Description:
After solid organ transplantation, the body generates an aggressive immune response because it recognizes the transplanted organ's antigens as a foreign antigen. Thus, treatment with immunosuppressive agents is necessary after an organ transplant to prevent organ rejection.
Antithymocyte Globulin (ATG) is a purified antibody preparation derived from rabbits or horses that have been hyperimmunized with human thymocytes. It is a potent immunosuppressive agent used primarily to prevent and treat acute cellular rejection following solid organ transplantation, including kidney, heart, and liver transplants. ATG is also employed in the management of acute aplastic anemia and other severe immune-mediated hematologic disorders. By targeting T-lymphocytes, ATG reduces the immune response, helping to prevent graft-versus-host disease and improve transplant outcomes.
Although ATG is highly effective, it can cause transient elevations in serum enzymes shortly after infusion, and it carries a risk of reactivating hepatitis B in susceptible patients. Common adverse effects include fever, chills, hypotension, and infusion-related reactions, which typically require careful monitoring during administration. Its mechanism, dosing, and safety profile necessitate skilled oversight by healthcare professionals. Overall, ATG remains an essential therapy in transplantation and certain hematologic conditions due to its ability to modulate the immune system effectively while reducing the risk of organ rejection and immune-mediated complications.
Antithymocyte Immunoglobulins Injection — third party manufacturing & bulk supply
Antithymocyte Immunoglobulins Injection 25mg, 100 mg, 500 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Antithymocyte Immunoglobulins Injection listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
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Frequently Asked Questions
Antithymocyte Immunoglobulin (ATG) is used primarily to prevent and treat acute organ transplant rejection, especially in kidney, heart, or liver transplantation. It is also used in the management of aplastic anemia and other severe immune-mediated hematologic disorders. ATG works by depleting T-lymphocytes, suppressing the immune response, and reducing the risk of graft-versus-host disease (GVHD) in transplant patients.
ATG is prepared from the serum of rabbits or horses that have been immunized with human thymocytes, resulting in antibodies that target human T-cells. These antibodies are purified to produce the immunoglobulin formulation.
Common trade names include Thymoglobulin, ATGAM, Grafalon, Fresenius ATG, and Thymoglobuline.
ATG products are manufactured by several pharmaceutical companies including Sanofi, Neovii Biotech, and Fresenius Kabi.
The generic name is Antithymocyte Immunoglobulin.
Common brand names include Thymoglobulin, ATGAM, Grafalon, Fresenius ATG, and Thymoglobuline.
ATG products are manufactured in several countries including the United States, Germany, Switzerland, and other regions by different pharmaceutical companies specializing in immunoglobulin therapies.
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