How to Source Desipramine hydrochloride for Pharmaceutical Formulation

Desipramine hydrochloride (Tablets, 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg) is classified under Antipsychotropic Drugs. It is therapeutically aligned with reference brands such as Norpramin (USA), Pertofrane(EU/UK). This guide highlights key sourcing factors buyers should consider when procuring high-quality Desipramine hydrochloride for formulation, R&D, or bulk manufacturing.

Product Overview: Desipramine hydrochloride is a tricyclic antidepressant (TCA) that increases the levels of norepinephrine and serotonin in the brain to improve mood and relieve depressive symptoms. It’s used to treat major depressive disorder and sometimes neuropathic pain or ADHD. It should be taken under medical supervision as it can cause side effects such as dry mouth, dizziness, constipation, and heart rhythm changes.

1. Regulatory Compliance & Documentation

Ensure suppliers provide:

• ✔ Valid DMF (Drug Master File)
• ✔ COA (Certificate of Analysis) for each batch
• ✔ GMP, ISO, or ICH Q7 compliance certificates

2. Purity, Grade & Specification Matching

Desipramine hydrochloride must meet exact grade and purity for your dosage form:

• ✔ USP / EP / JP grade verification
• ✔ Particle size distribution check
• ✔ Residual solvent and heavy metal limits

3. Supplier Reliability & Audit History

• ✔ Positive past audit reports
• ✔ Pharma client references
• ✔ Years of proven API manufacturing experience

4. Commercial Terms: Pricing, MOQ & Flexibility

• ✔ Transparent pricing
• ✔ Pilot batch MOQ flexibility
• ✔ Volume-based discounts

5. Lead Time, Inventory & Logistics

Typical lead time for Desipramine hydrochloride is 4–6 weeks.

• ✔ Emergency dispatch options
• ✔ Regional warehousing
• ✔ Special storage if needed

6. Formulation Support

• ✔ Technical datasheets
• ✔ Sample availability
• ✔ Stability study support

Conclusion

Sourcing Desipramine hydrochloride is more than procurement—it’s a strategic partnership. With its tablets form and 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg specification, choosing a compliant supplier ensures consistent quality and regulatory approval. Prioritize documentation, verify compatibility, and build relationships with transparent, reliable suppliers to secure long-term success.

Frequently Asked Questions For Sourcing of Desipramine hydrochloride